Linezolid Susceptibility And Potential Resistance Mechanisms Among Mrsa Isolated From Two Major Public Hospitals In Malaysia [PDF]
, 2014 Linezolid is the first antibiotic of a new structural class, the oxazolidinones, to be approved for clinical use in 35 years. This antimicrobial agent is broadly effective against drug-resistant gram-positive pathogens which commonly cause infections ...
Thiruchelvi , Pulingam
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Binding of [acetyl-14C] Trichodermin to the Peptidyl Transferase Centre of Eukaryotic Ribosomes [PDF]
, 1974 Mariano Barbacid, David Vázquez
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The mitochondrial methylation potential gates mitoribosome assembly
Nature CommunicationsS-adenosylmethionine (SAM) is the principal methyl donor in cells and is essential for mitochondrial gene expression, influencing RNA modifications, translation, and ribosome biogenesis.
Ruth I. C. Glasgow +15 more
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Three‐dimensional location of ribosomal protein BL2 from Bacillus stearothermophilus, a key component of the peptidyl transferase center [PDF]
, 1988 Wolfgang Hackl +2 more
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The ribosomal peptidyl transferase
, 2017 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, Malte, Rodnina, Marina
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Ribosomal Protein L27 Participates in both 50 S Subunit Assembly and the Peptidyl Transferase Reaction [PDF]
, 1998 Iwona K. Wower +2 more
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Chemistry and Biology of Streptogramin A Antibiotics [PDF]
, 2007 The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
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Recognition of Hybrid Peptidyl Carrier Proteins/Acyl Carrier Proteins in Nonribosomal Peptide Synthetase Modules by the 4′-Phophopantetheinyl Transferases AcpS and Sfp [PDF]
, 2002 Mohammad Reza Mofid +2 more
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]
, 2019 Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C +15 more
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Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451 [PDF]
, 2005 Matthias David Erlacher
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