Results 101 to 110 of about 33,711 (238)
Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
core +1 more source
Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity [PDF]
FEBS Letters, 1975 The transfer reaction with pA-fMet as a donor substrate is strongly stimulated by CMP, whereas the transfer reaction with CpApCpCpA-acLeu as a donor substrate is inhibited by CMP. These results indicate that the donor site of peptidyl transferase contains specific binding sites for the terminal adenosine and for the cytidylic acid residue in the ...
openaire +2 more sources
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva +3 more
wiley +1 more source
Mechanism of ribosome rescue by ArfA and RF2
eLife, 2017 ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample – of the 70S ribosome ...
Gabriel Demo +7 more
doaj +1 more source
Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]
, 2018 Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole +6 more
core +2 more sources
Protein Science, Volume 35, Issue 4, April 2026.Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez +6 more
wiley +1 more source
The mechanistic and evolutionary aspects of the 2'- and 3'-OH paradigm in biosynthetic machinery. [PDF]
, 2013 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Klipcan, Liron, Safro, Mark
core +2 more sources
The ribosome as a versatile catalyst: reactions at the peptidyl transferase center [PDF]
Current Opinion in Structural Biology, 2013 In all contemporary organisms, the active site of the ribosome--the peptidyl transferase center--catalyzes two distinct reactions, peptide bond formation between peptidyl-tRNA and aminoacyl-tRNA as well as the hydrolysis of peptidyl-tRNA with the help of a release factor. However, when provided with appropriate substrates, ribosomes can also catalyze a
openaire +3 more sources
Food and Energy Security, Volume 15, Issue 2, March/April 2026.ABSTRACT Heat stress increasingly threatens global wheat production as extreme temperature events become more frequent under climate change. To better understand the molecular basis of thermotolerance, we evaluated the heat responses of 30 elite wheat accessions and identified substantial natural variation in seedling survival (26.7%), plant height (26.
Junlong Jiang +6 more
wiley +1 more source
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]
, 2012 Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core +1 more source