Results 91 to 100 of about 33,711 (238)

Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Plant Biology, EarlyView.
Transcript correlation analysis allowed the identification of several key nodes in the complex regulatory network of plant iron metabolism. Abstract Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide.
I. Murgia, P. Morandini
wiley   +1 more source

Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus [PDF]

, 2017
In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a
Christie, Gail E., Johnson, Adam L., Peterson, Darrell L., Wall, Erin A.   +3 more
core   +2 more sources

Association mapping for hop cone chemistry and morphology identifies natural beneficial allele stacks

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Efforts are underway to increase the efficiency and precision of selection hop (Humulus lupulus L.) breeding using genomics. Little is known, however, about the genetic control of important traits like α‐and β‐acids contents, oil content, and cone morphological characteristics, all of which play an important role in determining the utility and
Shaun J. Clare, Peter Schmuker, Kayla Altendorf   +2 more
wiley   +1 more source

The Order Bacillales Hosts Functional Homologs of the Worrisome cfr Antibiotic Resistance Gene [PDF]

, 2012
The cfr gene encodes the Cfr methyltransferase that methylates a single adenine in the peptidyl transferase region of bacterial ribosomes. The methylation provides resistance to several classes of antibiotics that include drugs of clinical and veterinary
Hansen, Lykke H., Long, Katherine S., Planellas, Mercè H., Vester, Birte   +3 more
core   +1 more source

RNA aptamers to the peptidyl transferase inhibitor chloramphenicol

Chemistry & Biology, 1997
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand our understanding of molecular recognition by RNA and to ...
Burke, Donald H., Hoffman, David C., Brown, Analisa, Hansen, Mark, Pardi, Arthur, Gold, Larry   +5 more
openaire   +2 more sources

Environmental Stress Induces Altered Composition of Streptococcus mutans Membrane Vesicles: pH‐Driven Changes in Membrane Vesicle Production and Composition

Molecular Oral Microbiology, Volume 41, Issue 3, Page 145-157, June 2026.
ABSTRACT Bacteria produce membrane vesicles (MVs) in response to environmental stress and genetic changes. Previous studies have shown that MVs can trigger inflammatory responses and may serve as important mediators of host–microbe interactions. Given the dynamic nature of the oral microbiome, bacteria such as Streptococcus mutans are frequently ...
Taylor C. Boone, Swetha K. Shankar, Melodie L. Weller   +2 more
wiley   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor

Cell Reports, 2014
Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide.
Lukas Bischoff, Otto Berninghausen, Roland Beckmann   +2 more
doaj   +1 more source

A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl‐AMP Mimicry in NRPS

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A concise three‐step synthesis enables access to amino acid‐derived adenosine vinylsulfonamide (AVS) probes under mild conditions. Ba(OH)2‐mediated coupling suppresses epimerization, affording stereochemically defined probes that covalently capture nonribosomal peptide synthetase (NRPS) thioesterification states. LC–MS/MS confirms functional engagement
Naoto Haraguchi, Arisa Suto, Takashi Matsui, Yoshio Kodera, Yoshikazu Tanaka, Ryo Tanifuji, Hiroki Oguri   +6 more
wiley   +1 more source

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source