PRMT7 Is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity [PDF]
, 2004 We have identified a mammalian arginine N-methyltransferase, PRMT7, that can catalyze the formation of ω-N^G-monomethylarginine in peptides. This protein is encoded by a gene on human chromosome 16q22.1 (human locus AK001502).
Clarke, Steven +3 more
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A distinct translation initiation mechanism generates cryptic peptides for immune surveillance. [PDF]
PLoS ONE, 2008 MHC class I molecules present a comprehensive mixture of peptides on the cell surface for immune surveillance. The peptides represent the intracellular protein milieu produced by translation of endogenous mRNAs. Unexpectedly, the peptides are encoded not
Shelley R Starck +7 more
doaj +1 more source
Cotranslational folding of proteins on the ribosome.
, 2020 Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
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Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]
, 2017 Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Wei, Dong +6 more
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PLoS ONE, 2013 Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against
Ruofeng Shang +6 more
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Mechanisms of ribosome stalling by SecM at multiple elongation steps
eLife, 2015 Regulation of translating ribosomes is a major component of gene expression control network. In Escherichia coli, ribosome stalling by the C-terminal arrest sequence of SecM regulates the SecA-dependent secretion pathway.
Jun Zhang +5 more
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Machine learning approaches to optimize small-molecule inhibitors for RNA targeting
Journal of Cheminformatics, 2022 In the era of data science, data-driven algorithms have emerged as powerful platforms that can consolidate bioisosteric rules for preferential modifications on small molecules with a common molecular scaffold.
Hadar Grimberg +6 more
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Molecular Simulations of the Ribosome and Associated Translation Factors
, 2014 The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535) +3 more
core +6 more sources
Liver transplantation for type I and type IV glycogen storage disease [PDF]
, 1993 Progressive liver failure or hepatic complications of the primary disease led to orthotopic liver transplantation in eight children with glycogen storage disease over a 9-year period.
A. G. Tzakis +37 more
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Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain [PDF]
, 2012 Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal
Ames, Brian D. +6 more
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