Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. [PDF]
, 2007 Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target
Arias, Cesar A +6 more
core +1 more source
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +2 more sources
Characterization of Linezolid-Analogue L3-Resistance Mutation in Staphylococcus aureus
Microorganisms, 2023 In a previous study, a linezolid analogue, called 10f, was synthesized. The 10f molecule has an antimicrobial activity comparable to that of the parental compound. In this study, we isolated a Staphylococcus aureus (S.
Anna Zanfardino +7 more
doaj +1 more source
Nature Communications, 2021 The molecular events underlying the assembly and maturation of the early pre-60S particles during eukaryotic ribosome synthesis are not well understood. Here, the authors combine yeast genetics and biochemical experiments to characterise the functions of
Mariam Jaafar +16 more
doaj +1 more source
Impact of P-Site tRNA and antibiotics on ribosome mediated protein folding: studies using the Escherichia coli ribosome. [PDF]
PLoS ONE, 2014 BACKGROUND: The ribosome, which acts as a platform for mRNA encoded polypeptide synthesis, is also capable of assisting in folding of polypeptide chains.
Surojit Mondal +3 more
doaj +1 more source
Heterologous Production of Barnesin A, an NRPS-PKS Hybrid Containing a Rare Vinylogous Arginine Moiety. [PDF]
ChembiochemVinylogous (vin) amino acids are rare and highly reactive building blocks of peptidic natural products. We report the heterologous production of the vin‐arginine harboring barnesin A, a potent cysteine protease inhibitor. Barnesin A biosynthesis is suggested to involve FabD from primary metabolism, and the corresponding NRPS–PKS megaenzyme shows strict
Balluff S, Dayras M, Beemelmanns C.
europepmc +2 more sources
A proteomic investigation of Fusobacterium nucleatum alkaline-induced biofilms [PDF]
, 2012 Background: The Gram negative anaerobe Fusobacterium nucleatum has been implicated in the aetiology of periodontal diseases. Although frequently isolated from healthy dental plaque, its numbers and proportion increase in plaque associated with disease ...
Chew, J., Fuss, J., Gully, N., Zilm, P.
core +3 more sources
Characterizing fruit ripening in plantain and Cavendish bananas: A proteomics approach [PDF]
, 2020 The fruit physiology of banana cultivars other than Cavendish is poorly understood. To study the ripening process, samples were taken daily from plantain and Cavendish bananas and the ripening stages were determined. We present data from the green to the
Bhuiyan, F. +3 more
core +1 more source
Helicobacter pylori and Epstein-Barr virus infection in gastric diseases: Correlation with IL-10 and IL1RN polymorphism. [PDF]
, 2019 Introduction: Helicobacter pylori and Epstein-Barr virus (EBV) infection have recently 23 been shown to be associated with gastric diseases. Polymorphisms in genes encoding 24 cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN ...
Anna Giammanco +11 more
core +1 more source
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source