Results 21 to 30 of about 33,711 (238)
Peptidyl Transferase Center and the Emergence of the Translation System. [PDF]
Life (Basel), 2017 In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus.
Torres de Farias S +2 more
europepmc +4 more sources
Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids. [PDF]
RNA, 2017 Lehmann J.
europepmc +3 more sources
Ancestral Insertions and Expansions of rRNA do not Support an Origin of the Ribosome in Its Peptidyl Transferase Center. [PDF]
J Mol Evol, 2015 Caetano-Anollés G.
europepmc +3 more sources
The Ribosomal Peptidyl Transferase [PDF]
Molecular Cell, 2007 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, M., Rodnina, M.
openaire +3 more sources
REVIEW OF HPLC METHODS FOR DETERMINATION OF AZITHROMYCIN IN DIFFERENT SAMPLES
The Iraqi Journal of Medical Sciences, 2022 Azithromycin is a semi-synthetic macrolide antibiotic of the azalide groups. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome.
Rawa M. Taqi +2 more
doaj +9 more sources
Nature Communications, 2021 Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and ...
Caillan Crowe-McAuliffe +13 more
doaj +1 more source
Structural basis for late maturation steps of the human mitoribosomal large subunit
Nature Communications, 2021 Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and ...
Miriam Cipullo +4 more
doaj +1 more source
Antibiotics, 2023 In a previous study published by our group, successful modification of the antibiotic chloramphenicol (CHL) was reported, which was achieved by replacing the dichloroacetyl tail with alpha and beta amino acids, resulting in promising new antibacterial ...
Artemis Tsirogianni +4 more
doaj +1 more source
Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
Nature Communications, 2021 Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles of ...
Hauke S. Hillen +7 more
doaj +1 more source
Antibiotics, 2021 To combat the dangerously increasing pathogenic resistance to antibiotics, we developed new pharmacophores by chemically modifying a known antibiotic, which remains to this day the most familiar and productive way for novel antibiotic development.
Artemis Tsirogianni +5 more
doaj +1 more source