Results 11 to 20 of about 33,711 (238)

The Bacillus subtilis ywbD gene encodes RlmQ, the 23S rRNA methyltransferase forming m⁷G2574 in the A-site of the peptidyl transferase center. [PDF]

RNA, 2023
Wolff P, Labar G, Lechner A, Van Elder D, Soin R, Gueydan C, Kruys V, Droogmans L, Roovers M.   +8 more
europepmc   +3 more sources

Structural insights into context-specific inhibition of bacterial translation by macrolides [PDF]

Nature Communications
The ribosome’s peptidyl transferase center (PTC) catalyzes peptide bond formation during protein synthesis and is targeted by many antibiotic classes. Remarkably, macrolides that bind in the peptide exit tunnel some ~10 Å away from the PTC also remotely ...
Egor A. Syroegin, Elena V. Aleksandrova, Artem A. Kruglov, Madhura N. Paranjpe, Maxim S. Svetlov, Yury S. Polikanov   +5 more
doaj   +2 more sources

The Peptidyl Transferase Center: a Window to the Past. [PDF]

Microbiol Mol Biol Rev, 2021
In his 2001 article, “Translation: in retrospect and prospect,” the late Carl Woese made a prescient observation that there was a need for the then-current view of translation to be “reformulated to become an all-embracing perspective about which 21st century Biology can develop” (RNA 7:1055–1067, 2001, https://doi.org/10.1017 ...
Tirumalai MR, Rivas M, Tran Q, Fox GE.
europepmc   +3 more sources

The Photochemical Inactivation of Peptidyl Transferase Activity [PDF]

European Journal of Biochemistry, 1975
The photochemical oxidation of the 50‐S ribosomal subunit results in a rapid irreversible loss of peptidyl transferase activity. The first‐order rate of inactivation occurring during the first forty minutes suggests that a single reactive group is being inactivated.
Kwong K. WAN, Nasir Zahid, R.M. Baxter
openalex   +4 more sources

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome. [PDF]

Nat Struct Mol Biol, 2009
Protein synthesis is catalyzed in the peptidyl transferase center (PTC), located in the large (50S) subunit of the ribosome. No high-resolution structure of the intact ribosome has contained a complete active site including both A- and P-site tRNAs.
Voorhees RM, Weixlbaumer A, Loakes D, Kelley AC, Ramakrishnan V.   +4 more
europepmc   +4 more sources

Loss of Conserved rRNA Modifications in the Peptidyl Transferase Center Leads to Diminished Protein Synthesis and Cell Growth in Budding Yeast. [PDF]

Int J Mol Sci
Leppik M, Pomerants L, Põldes A, Mihkelson P, Remme J, Tamm T.   +5 more
europepmc   +3 more sources

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest. [PDF]

Nucleic Acids Res, 2018
Murina V, Kasari M, Hauryliuk V, Atkinson GC.   +3 more
europepmc   +3 more sources

Activities of the peptidyl transferase center of ribosomes lacking protein L27. [PDF]

RNA, 2015
Maracci C, Wohlgemuth I, Rodnina MV.
europepmc   +3 more sources

Identification of the Target for a Transition Metal-α-Amino Acid Complex Antibiotic Against Mycobacterium smegmatis

Frontiers in Pharmacology, 2021
Spontaneous mutants of Mycobacterium smegmatis strain mc2155 resistant to 1-PG (iridium-L-phenylglycine complex), an antimycobacterial antibiotic, were isolated.
George W. Karpin, George W. Karpin, Joseph S. Merola, Joseph S. Merola, Joseph O. Falkinham, Joseph O. Falkinham   +5 more
doaj   +1 more source

A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal peptidyl transferase inhibitor [PDF]

Schwaller N, Andenmatten D, Luginbühl J, Rabl J, Chambon M, Vesin J, Turcatti G, Karousis ED.   +7 more
europepmc   +2 more sources