Results 201 to 210 of about 163,491 (263)
The Peptidyl Transferase Center: a Window to the Past
Microbiology and Molecular Biology Reviews, 2021 In his 2001 article, “Translation: in retrospect and prospect,” the late Carl Woese made a prescient observation that there was a need for the then-current view of translation to be “reformulated to become an all-embracing perspective about which 21st century Biology can develop” (RNA 7:1055–1067, 2001, https://doi.org/10.1017 ...
Madhan R. Tirumalai +3 more
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Scientific Reports, 2016 Phosphopantetheinyl transferases (PPTases) play essential roles in both primary metabolisms and secondary metabolisms via post-translational modification of acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs).
Yue-Yue Wang, Hui Jiang, Yong-Quan Li
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A Model for Protein Synthesis Involving the Intermediate Formation of Peptidyl-5S RNA
Proceedings of the National Academy of Sciences of the United States of America, 1971 I. Raacke
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Peptidyl transferase and beyond
Biochemistry and Cell Biology, 1995The peptidyl transferase center of the Escherichia coli ribosome encompasses a number of 50S-subunit proteins as well as several specific segments of the 23S rRNA. Although our knowledge of the role that both ribosomal proteins and 23S rRNA play in peptide bond formation has steadily increased, the location, organization, and molecular structure of ...
Wower, J +5 more
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Transesterification by Peptidyl Transferase
Nature, 1970Peptidyl transferase, the enzyme which catalyses formation of peptide bonds, can be stimulated by CCA, the 3′-terminus of tRNA, to catalyse also a transesterification reaction involving nucleophilic attack of Met-tRNAfMet by ethanol to yield fMet-ethyl ester.
E, Scolnick +3 more
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Masking of peptidyl transferase activity in polyribosomes
Archives of Biochemistry and Biophysics, 1975Abstract The peptidyl transferase activity of polysomes from Escherichia coli , rabbit reticulocytes and chick embryos, assayed in the fragment reaction, is 3- to 10-fold lower than the corresponding activity of single ribosomes. The polysomal peptidyl transferase activity is restored in full under conditions of in vitro protein synthesis that ...
V R, Leick, R F, Santerre, R, Kaempfer
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Molecular aspects of the ribosomal peptidyl transferase
Biochemical Society Transactions, 2002The proteins in a living cell are synthesized on a large bipartite ribonucleoprotein complex termed the ribosome. The peptidyl transferase, which polymerizes amino acids to yield peptides, is localized on the large subunit. Biochemical investigations over the past 35 years have led to the hypothesis that rRNA has a major role in all ribosomal functions.
Barta, Andrea +4 more
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A Tale of Water Molecules in the Ribosomal Peptidyl Transferase Reaction.
Biochemistry, 2022The peptidyl transferase center (PTC) in the large subunit of the ribosome plays a critical role in protein synthesis by catalyzing the formation of peptide bonds with an astounding speed of about 15 to 20 peptide bonds per second.
Qiang Wang, Haibin Su
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Peptidyl transferase: A new method for kinetic studies
Biochemical and Biophysical Research Communications, 1972The reaction of N-Acetyl-phenylalanyl-t-RNA with E.coli ribosomes in the presence of poly Uridylic acid, guanosine 5′-triphosphate, and initiation factors (ribosomal wash), leads to the formation of N-Acetyl-phenylalanyl-RNA-ribosome-poly Uridylic acid complex, which can be isolated on a cellulose nitrate filter.
R, Fico, C, Coutsogeorgopoulos
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