Results 91 to 100 of about 124,195 (340)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

The Effects of Men\u27s Lacrosse Protective Equipment on Thermoregulation and Perceptions During Exercise Heat Stress [PDF]

, 2019
The effects of men\u27s lacrosse protective equipment on thermoregulation and perceptions during exercise heat stress Amanda P. Glasgow: Exercise Science Research Center, University of Arkansas, Fayetteville, AR.
Glasgow, Amanda
core   +3 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

THE RELEVANT USE OF A TRADITIONAL TUNISIAN GAME ‘‘RAQUASSA’’ FOR CARDIOVASCULAR SOLICITATION IN SCHOOL CHILDREN

Biology of Sport, 2013
Objective: The purpose of this study was to assess whether a lesson of physical activity based on a traditional Tunisian game could be a useful tool for soliciting the cardiovascular system in children.
Johnny Padulo, Mohamed Elloumi, Wassim Moalla, Tarak Jebali   +3 more
doaj   +1 more source

Moderating influence of dominant attentional style and exercise intensity on responses to asynchronous music [PDF]

, 2013
Copyright @ 2013 Human Kinetics as accepted for publication. This is the author's accepted manuscript. The final published article is available from the link below.We examined independent and combined influences of asynchronous music and dominant ...
Karageorghis, CI
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training session in female cross-country skiers

Frontiers in Physiology
PurposeThis study investigated duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training (LIT) session in female cross-country (XC) skiers.MethodsTwelve national-level female XC skiers (age:21.4 ± 2.7 ...
Per-Øyvind Torvik, Guro Strøm Solli, Rune Kjøsen Talsnes, Øyvind Sandbakk   +3 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A comparison of sessional ratings of perceived exertion to cardiovascular indices of exercise intensity during competition in elite field hockey players

Biomedical Human Kinetics, 2018
Study aim: Recent evidence has revealed a reduction in the strength of correlation between ratings of perceived exertion and a heart rate (HR) derived training load in elite field hockey players during competition.
Perrotta Andrew Scott, Warburton Darren E. R.   +1 more
doaj   +1 more source