Results 111 to 120 of about 2,699,721 (304)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Investigation of the Resilience, Self-Efficacy, and Perceived Social Support of Gifted Students

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Özel Eğitim Dergisi
Introduction: This research aimed to analyze the levels of psychological resilience in terms of different variables, self-efficacy, and perceived social support among gifted students, investigate the relationships between these variables, and examine the
Ayşegül Kılıçaslan Çelikkol, Özge Yıldırım   +1 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Perceived social support on objective measured sedentary behavior of stroke patients: the mediating role of exercise self-efficacy

Frontiers in Psychology
IntroductionAs stroke patients may have impaired motor function, there may have increased sedentary behavior. Factors associated with sedentary behavior need to be explored to develop targeted interventions.
Jianing Wei, Fanjiayi Yang, Xiaofang Dong   +2 more
doaj   +1 more source

Effect of Perceived Social Support on Psychache: Mediating Effect of Psychological Resilience

Iranian Journal of Public Health, 2022
Background: As education develops, it proposes increasing requirements on the quality of teachers. Thus, attention on the mental health problems of teachers has also been gaining increasing attention.
Ling Zhang, Jinxia Pang, Fangli Zhu
doaj  

The Relation among Parental Factors and Achievement of African American Urban Youth [PDF]

, 2009
Research has repeatedly suggested that SES is a major factor in diminishing academic achievement of African American urban youth; however, there are other factors also influencing children’s achievement.
Wilson, Clancie
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Factors associated with perceived social support among adolescents in Gamo Zone, Southern Ethiopia: a community-based cross-sectional study

Frontiers in Psychiatry
IntroductionPerceived social support plays a crucial role in adolescent development, health, well-being, and resilience. Understanding the factors associated with perceived social support among adolescents is essential for designing effective ...
Negussie Boti Sidamo, Amene Abebe Kerbo, Yohannes Dibaba Wado, Mengistu Meskele Koyira, Kassa Daka Gidebo   +4 more
doaj   +1 more source

Evaluation of relationship self esteem with perceived social support in patients with Multiple Sclerosis‏ [PDF]

, 2013
Background: Multiple Sclerosis is the chronic and progressive diseases of central neurons in adolescent that almost is accidently and had psychological effects on individuals that this subject can occurrence after change of patients trusts toward self ...
Ghodusi Borujeni, Mansureh., Heidari, Mohammad., Purazizi, Sadigheh., Shahbazi, Sara., Shirvani, Mina.   +4 more
core