Results 91 to 100 of about 2,726,873 (304)

Perceived Social Support among Hospital Personnel and its Influential factors: A case study [PDF]

, 2011
Background and aim: Increasing productivity in an organization requires providing various conditions; important of all is human factor. Social support is known as a psychological factor in workplace that effect on productivity of human factor.
Heidari, Hayedeh., Mahboobi, Mohammad., Mardani Hamuleh, Marjan., Raeisi, Pouran.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The neural correlates of perceived social support and its relationship to psychological well-being

Frontiers in Behavioral Neuroscience
IntroductionPerceived social support is considered to play a significant role in promoting individuals’ health and well-being, and yet the neural correlates of perceived social support were not fully understood. An exploration of the neural correlates of
Huanhua Lu, Yiying Song, Xu Wang, Jia Liu   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effective PSHE education: values, purposes and future directions [PDF]

, 2012
This article explores the perceived effectiveness of personal, social, health and economic (PSHE) education in primary and secondary schools. It outlines the relationship between perceived effectiveness and a range of explanatory factors, linking these ...
Ben Willis, Formby E., Hall S., HM government, Lucy Clague, Mike Coldwell, Vygotsky L.   +6 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Relationship Between Perceived Social Support and Anxiety in Pregnant Women With a History of Abortion [PDF]

Journal of Holistic Nursing and Midwifery
Introduction: Abortion is a shocking and traumatic event that can lead to psychological disorders, such as anxiety, in women. Perceived social support of these women can be an appropriate method for helping them deal with challenging life events after ...
Fateme Kadkhodaei, Maryam Niknami, Zahra Bostani Khalesi, Saman Maroufizadeh   +3 more
doaj  

The Relation Between Body Esteem With Self Esteem And Perceived Social Support In Multiple Sclerosis Patients–Assessment. [PDF]

, 2016
:Background& Objective: Multiple sclerosis (MS) is a disabled illness of that can highly effect on body esteem and self-esteem in patients. This study was to examine the relation between body esteem with self-esteem and perceived social support in MS ...
Ali Sheikhi, Rahim., Ghodusi Borujeni, Mansooreh., Heidari, Mohammad., Shirvani, Mina.   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source