Results 81 to 90 of about 18,641,860 (291)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Relationship status and perceived support in the social regulation of neural responses to threat

, 2017
Strong social ties correspond with better health and well being, but the neural mechanisms linking social contact to health remain speculative.
Lane Beckes, Casey L Brown, Marlen Z Gonzalez, Maresh, Erin L, Brown, Casey L, Gonzalez, Marlen Z, Erin L Maresh, James A Coan, Karen Hasselmo, Coan, James A, Beckes, Lane, Hasselmo, Karen   +11 more
core   +1 more source

Relationship Between Perceived Social Support and Anxiety in Pregnant Women With a History of Abortion [PDF]

Journal of Holistic Nursing and Midwifery
Introduction: Abortion is a shocking and traumatic event that can lead to psychological disorders, such as anxiety, in women. Perceived social support of these women can be an appropriate method for helping them deal with challenging life events after ...
Fateme Kadkhodaei, Maryam Niknami, Zahra Bostani Khalesi, Saman Maroufizadeh   +3 more
doaj  

An Investigation Of Perceived Social Support And Social Self Efficacy In Adolescents

İlköğretim Online, 2013
Bu araştırmanın amacı ergenlerde sosyal yetkinliğin, algılanan sosyal destek açısından incelenmesidir. Araştırma ilişkisel tarama modeline uygun olarak desenlenmiş ve 365’ i kız ve 252’si erkek olmak üzere 617 lise öğrencisi üzerinde gerçekleştirilmiştir. Öğrenciler 15–19 (x=16,92 ve Ss=1.03) yaşları arasındadır.
TRAŞ, Zeliha, ARSLAN, Emel
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The neural correlates of perceived social support and its relationship to psychological well-being

Frontiers in Behavioral Neuroscience
IntroductionPerceived social support is considered to play a significant role in promoting individuals’ health and well-being, and yet the neural correlates of perceived social support were not fully understood. An exploration of the neural correlates of
Huanhua Lu, Yiying Song, Xu Wang, Jia Liu   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Mediating Role of Self-Perceived Burden Between Social Support and Fear of Progression in Renal Transplant Recipients: A Multicenter Cross-Sectional Study

, 2023
Sainan Liu,1,* Ying Zhang,1,* Qi Miao,1 Xu Zhang,1 Xiaoyu Jiang,1 Tiantian Chang,1 Xiaofei Li2 1The First Affiliated Hospital of China Medical University, Shenyang, 110000, People’s Republic of China; 2Transplantation and Hepatobiliary Department,
Miao Q, Li X, Zhang Y, Zhang X, Jiang X, Chang T, Liu S   +6 more
core  

Gender-Based Violence, Coping Strategies and Perceived Social Support

Psicología, Conocimiento y Sociedad, 2017
El fenómeno de la violencia de género es un problema muy complejo que trasciende los tiempos y se da en múltiples culturas. Sin embargo, en las últimas décadas, la ruptura del tabú que comportaba tradicionalmente la violencia hacia la mujer ha dado lugar
Alicia Pérez-Tarrés, Leonor Cantera, Joilson Pereira   +2 more
doaj