Results 121 to 130 of about 1,677,146 (294)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Pursuing uniqueness through competition : perceived power distance as moderator
, 2020 This paper explores a relationship between the need for uniqueness in an individual and their competitiveness. Perceived power distance of their society is taken into account as a moderator that could positively influence the postulated relationship ...
Leong, Shu Ting
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Relationships Among Tourists' Needs For Uniqueness, Perceived Authenticity And Behavioral Intentions
, 2016 This study tested a structural model which investigates the relationships among tourists’ need for uniqueness, perceived authenticity (object-based authenticity and existential authenticity) and behavioral intentions to consume cultural and heritage destinations.
openaire +2 more sources
, 2015 [[abstract]]There has been considerable research into the global phenomenon of foreign brand consumption, however, only few studies have empirically explored how value creation influences brand preference and purchase intentions of Asian consumers.
林珍納, Nazareno, Jenelyn Sabayton
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Uniqueness Bias:Why It Matters, How to Curb It [PDF]
The paper explores "uniqueness bias," a behavioral bias defined as the tendency of planners and managers to see their decisions as singular. For the first time, uniqueness bias is correlated with forecasting accuracy and performance in real-world project
Christodoulou, M.D. +2 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
How Do I Look? The Impact of Unique and Intermediate Hues on Perceived Attractiveness
Color Research & ApplicationABSTRACTHering's unique hues (uHs) are hypothesized to exhibit enhanced perceptual salience due to their role in the opponent‐process theory of color vision, which posits that human color perception is structured around two opposing pairs: red–green and yellow–blue.
Renzo Shamey, Zhenhua Luo
openaire +1 more source