Results 31 to 40 of about 804,363 (217)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cross Calibration of Telescope Optical Throughput Efficiencies using Reconstructed Shower Energies for the Cherenkov Telescope Array

, 2015
For reliable event reconstruction of Imaging Atmospheric Cherenkov Telescopes (IACTs), calibration of the optical throughput efficiency is required. Within current facilities, this is achieved through the use of ring shaped images generated by muons ...
Bernloehr, K., Hofmann, W., Mitchell, A. M. W., Parsons, R. D.   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Impact of Accumulated Dust on Performance of Two Types of Photovoltaic Cells: Evidence from the South of Jordan

International Journal of Renewable Energy Development, 2022
This paper examines the impact of accumulated dust on two types of photovoltaic (PV) cells in the performance of solar panels facility located in the southern part of Jordan between January to August 2020.
Abdullah Marashli, Ghadeer Nyazi Al Shaba'an, Waed Al-Twaissi, Mohammad Shalby, Hani Al-Rawashdeh   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Estimation techniques utilizing dual auxiliary variables in stratified two-phase sampling

AIMS Mathematics
In this research paper, an improved set of estimators for finding the finite population variance of a study variable under a stratified two-phase sampling design is introduced. These estimators rely on information about extreme values and the ranks of an
Olayan Albalawi
doaj   +1 more source

The Relative Efficiency of Commercial Banks in Pakistan with Respect to Size and Ownership Structure During and After Global Financial Crisis

Journal of Accounting and Finance in Emerging Economies, 2018
Purpose: This study has been carried out to find out the relative efficiency of the commercial banks in Pakistan over a five- year period from 2006 to year 2010 using Frontier Approach of efficiency.
Allah Bakhsh Khan, Syed Zulfiqar Ali Shah, Muhammad Abbas, Qaiser Maqbool khan   +3 more
doaj   +1 more source

Estimating relative sunshine duration from commonly available meteorological variables for simulating biome distribution in the Carpathian Region

Hungarian Geographical Bulletin, 2022
Bright sunshine duration (BSD) data are required for simulating biomes using process-based vegetation models. However, monthly global paleoclimate datasets that can be used in paleo data–model comparisons do not necessarily contain BSD or radiation data.
Zoltán Szelepcsényi, Hajnalka Breuer, Nándor Fodor   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source