Results 51 to 60 of about 159,648 (220)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficient estimation method of population mean with non-response and observational error under ORRT models

Research in Statistics
This study addresses the difficulties faced by surveyors in collecting responses to sensitive questions, which lead to non-sampling errors such as non-response and observational error.
Sunil Kumar, Chanda Rani, Housila P. Singh, J. P. S. Joorel   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Increased Statistical Efficiency in a Lognormal Mean Model

Journal of Probability and Statistics, 2014
Within the context of clinical and other scientific research, a substantial need exists for an accurate determination of the point estimate in a lognormal mean model, given that highly skewed data are often present.
Grant H. Skrepnek, Ashok Sahai
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Highly Efficient Terahertz Waveguide Using Two-Dimensional Tellurium Photonic Crystals with Complete Photonic Bandgaps

Crystals
A novel, highly efficient terahertz fully polarized transmission line is designed by two-dimensional tellurium photonic crystals consisting of square lattice rod arrays with a complete photonic bandgap.
Yong Wang, Luyao Feng, Hongwei Huang, Zhifeng Zeng, Yuhan Liu, Xiaotong Liu, Xingquan Li, Kaiming Yang, Zhijian Zheng, Biaogang Xu, Wenlong He, Shaobin Zhan, Wenli Wang   +12 more
doaj   +1 more source

Evaluation of Origanum vulgare L. essential oil as a source of toxicant and an inhibitor of physiological parameters in diamondback moth, Plutella xylustella L. (Lepidoptera: Pyralidae)

Journal of the Saudi Society of Agricultural Sciences, 2017
The effect of essential oil of Origanum vulgare L. a medicinal plant was studied on toxicity, physiology and biochemical characteristics of diamondback moth Plutella xylustella L. in controlled condition.
Mahsa Nasr, Jalal Jalali Sendi, Saeid Moharramipour, Arash Zibaee   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effects of asafoetida, geranium and walnut leaves essential oils on nutritional indices and progeny reduction on Rhyzopertha dominica adults (Coleoptera: Bostrychidae)

Journal of Crop Protection, 2016
In this study, the efficiency of essential oils from asafoetida, Ferula assa foetida L.,geranium, Pelargonium hortorum L.H. Bailey and walnut leaves, Juglans regia F. was investigated on nutritional indices of Rhyzopertha dominica (F.) adults.
Rahim Bahrami, Farhan Kocheili, Masumeh Ziaee   +2 more
doaj