Results 161 to 170 of about 73,941 (208)

Local drug delivery for percutaneous coronary intervention

Pharmacology & Therapeutics, 2011
Since the first successful coronary angioplasty by Andreas Grüntzig in 1977, the field of percutaneous coronary intervention (PCI) has expanded rapidly. Rapid technological refinement has seen equipment and complementary pharmacotherapy to improve the outcome of PCI evolve dramatically, driven by clinical need and enormous market forces.
S, Sharma, C, Christopoulos, N, Kukreja, D A, Gorog   +3 more
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Topical drug delivery: History, percutaneous absorption, and product development

Advanced Drug Delivery Reviews, 2021
Topical products, widely used to manage skin conditions, have evolved from simple potions to sophisticated delivery systems. Their development has been facilitated by advances in percutaneous absorption and product design based on an increasingly mechanistic understanding of drug-product-skin interactions, associated experiments, and a quality-by ...
Michael S, Roberts, Hanumanth S, Cheruvu, Sean E, Mangion, Azadeh, Alinaghi, Heather A E, Benson, Yousuf, Mohammed, Amy, Holmes, John, van der Hoek, Michael, Pastore, Jeffrey E, Grice   +9 more
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Percutaneous Delivery of Antihypertensive Agents: Advances and Challenges

AAPS PharmSciTech, 2020
Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availability is an ongoing challenge.
Kevin Ita, Sharon Ashong
openaire   +2 more sources

Local Delivery of Therapeutics for Percutaneous Coronary Intervention

Current Drug Delivery, 2011
Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attractive option to maintain effective
Karen L, Kennedy, Alexandra R, Lucas, Wankei, Wan   +2 more
openaire   +2 more sources

Percutaneous Drug Delivery to the Hair Follicle

Journal of Toxicology: Cutaneous and Ocular Toxicology, 2001
Unique biochemical and immunological events dictate the complex cyclic growth and differentiation patterns of hair follicles and their associated sebaceous glands (1), structures that are collectively referred to as pilosebaceous units. Once regarded as mere evolutionary remnants, hair follicles and sebaceous glands have been recognized increasingly as
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Hyaluronic Acid for Percutaneous Drug Delivery

2015
Hyaluronic acid, a high-molecular-weight biopolymer, is of special interest as carrier material in drug delivery due to its biocompatibility, biodegradability, special viscoelastic properties, as well as its ability to create a dense network in which drugs might be incorporated. Hyaluronic acid has a broad applicability in various conditions such as in
Sarah Hedtrich, Wolfgang Frieß
openaire   +1 more source

Percutaneous Absorption and Dermal Delivery of Cyclosporin A

Journal of Pharmaceutical Sciences, 1995
The present study deals with attempts to deliver cyclosporin A into the deeper skin and some of the fundamental reasons why this proves so difficult. Because of different physicochemical requirements for the solution and activity of cyclosporin A and the enhancer, n-decylmethyl sulfoxide, it was hard to demonstrate increases in permeation of ...
H K, Choi, G L, Flynn, G L, Amidon
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Percutaneous Absorption: Mechanisms—Methodology—Drug Delivery

Archives of Dermatology, 1990
The first edition of this book, published in 1985, was the result of a symposium on percutaneous absorption held at the Food and Drug Administration in 1983. This area of dermatology continues to expand rapidly, fueled by the pharmaceutical industry's interest in the skin as a route for systemic drug delivery and the government's concern over the skin ...
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Physicochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine

International Journal of Pharmaceutics, 2003
The objective of this work is to investigate the percutaneous permeability of 2,3,5,6-tetramethylpyrazine (TMP), an active ingredient originally isolated from Ligusticum wallichii Franch. Certain physicochemical properties of TMP, including its partition coefficient and pH-solubility profile, were studied.
Xiaohong, Qi, Chrisita, Ackermann, Duxin, Sun, Minli, Sheng, Huimin, Hou   +4 more
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Percutaneous delivery system for nicotinamide transdermal therapeutic system

Perspektivnye Materialy, 2023
Recently, antioxidants, one of which is nicotinamide, have often been used in the treatment of a number of chronic cardiovascular, autoimmune, skin diseases, and diabetes mellitus. Taking into account the frequent and long-term use of nicotinamide, it seems appropriate to the authors to create a new dosage form of a transdermal therapeutic system (TTS)
E. G. Kuznetsova, V. A. Ryzhikova, L. A. Salomatina, O. M. Kuryleva, V. I. Sevastianov   +4 more
openaire   +1 more source