Results 111 to 120 of about 206,780 (273)

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao   +11 more
wiley   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong   +17 more
wiley   +1 more source

Variation and development of the turtle chondrocranium, with a description of the common musk turtle (Sternotherus odoratus, Kinosternidae, Cryptodira, Testudines)

open access: yesThe Anatomical Record, EarlyView., 2023
Abstract Based on histological cross‐sections, the chondrocranium of the common musk turtle (Sternotherus odoratus) was reconstructed, described, and compared with other turtles. It differs from that of other turtle chondrocrania by possessing elongated, slightly dorsally orientated nasal capsules with three dorsolateral foramina, which might be ...
Luca Leicht   +2 more
wiley   +1 more source

Multicontinuum homogenization in perforated domains [PDF]

open access: yesarXiv
In this paper, we develop a general framework for multicontinuum homogenization in perforated domains. The simulations of problems in perforated domains are expensive and, in many applications, coarse-grid macroscopic models are developed. Many previous approaches include homogenization, multiscale finite element methods, and so on.
arxiv  

Tetrahedral Nitrogen Atoms Arrangement in A‐Site Cations: A New Approach for Regulating Sensitivity and Energy of Perovskite Energetic Materials

open access: yesAdvanced Science, EarlyView.
The urotropine is selected as the A‐site cation in PEMs, and four urotropine‐based PEMs ([C6H14N4][M(ClO4)3]) are successfully prepared. Compared with the cubic PEMs, the crystal structure of the urotropine‐based PEMs has an expansion along the c‐axis.
Shiyong Chen   +10 more
wiley   +1 more source

Development of multi-physics finite element model to investigate electromagnetic forming and simultaneous multi-point perforations of aluminium tube [PDF]

open access: yes
Electromagnetic forming and perforations (EMFP) are complex and innovative high strain rate processes that involve electromagnetic-mechanical interactions for simultaneous metal forming and perforations. Instead of spending costly resources on repetitive experimental work, a properly designed numerical model can be effectively used for detailed ...
arxiv   +1 more source

Surface‐Engineered Cenospheres Encapsulating Phase Change Materials for Functional Cementitious Composites

open access: yesAdvanced Science, EarlyView.
The global energy demand drives the need for advanced energy‐efficient building solutions. While current polymeric‐shell microencapsulated PCMs show promise for thermal energy storage, their use in cementitious materials is challenged by poor shell strength and interfacial bonding. This study develops novel cement‐compatible microencapsulated PCM using
Sahand Rahemipoor   +7 more
wiley   +1 more source

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