Results 61 to 70 of about 1,722,070 (244)

FE-Study on the Effect of Gradient Concrete on Early Constraint and Crack Risk

Applied Sciences, 2018
In long-lasting mass concrete structures the desired material properties of the concrete mix to realize a durable concrete and a concrete surface without cracks conflict with each other.
Emanuel Strieder, Raimund Hilber, Elisabeth Stierschneider, Konrad Bergmeister   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Resilient by design: the case for increasing resilience of buildings and their linked food-energy-water systems

Elementa: Science of the Anthropocene, 2018
The resilience of buildings and food, energy, and water systems (FEWS) to natural or manmade disruptions are closely linked. The resilience of a building goes beyond the safety of its structural elements and must include the resilience of its supporting ...
Iris Tien
doaj   +1 more source

Performance Based Codes and Performance Based Fire Safety Design.

Fire Science and Technology, 1999
This paper discusses the needs for performance-based approach and its ideal structure in the area of building fire safety. To demonstrate the needs for performance based approach, the limitation of the trade off system was identified using the alternative solutions for smoke vent as an example.
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Influence of Panel Zone Modeling on the Seismic Behavior of Steel Moment-Resisting Frames: A Numerical Study

Applied Mechanics
In the seismic design of steel moment-resisting frames (MRFs), the panel zone region can significantly affect overall ductility and energy-dissipation capacity.
Nicos A. Kalapodis
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Thermodynamically consistent damage-plasticity model for fire-resistant design and optimization of reinforced concrete beams

Frontiers in Materials
Current fire design methods of reinforced concrete structures are marred with inaccurate model representation, undisciplined parameter study, and limited optimization applications.
Wu Feng, Wu Feng, Xu Yang, Tengku Anita Raja Hussin   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source