Results 71 to 80 of about 1,722,070 (244)
Performance-Based Design Approach for Tailored Acoustic Surfaces [PDF]
, 2019 The acoustics of architecture has a large influence on the physical and psychological state of people, impacting on their communication, concentration and behaviour. Nevertheless, the sound issues of the interior of common spaces are often faced in the last stage of the design process, as an accurate acoustic design requires a high level of expertise ...
M. Zheliazkova, A. Giglio, I. Paoletti
openaire +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Journal of Asian Architecture and Building EngineeringEvolutionary optimization has become a widely adopted approach in performance-based building design. It enables the discovery of high-fitness solutions through iterative search processes.
Zexu Deng +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Performance-Based Placement Design of Tuned Electromagnetic Inertial Mass Dampers
Frontiers in Built Environment, 2017 This paper presents a performance-based placement design method for the control of the earthquake responses of a multistory building using tuned electromagnetic inertial mass dampers (T-EIMDs).
Yutaka Nakamura, Tetsuya Hanzawa
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Damage Index-Based Lower Bound Structural Design
Frontiers in Built Environment, 2018 The scope of the work is to detect the most appropriate damage index, able to provide a reliable description of the structural damage level. This damage index is used to formulate a performance-based design framework to be used as a design tool for ...
Chara Ch. Mitropoulou +3 more
doaj +1 more source
PERFORMANCE-BASED SEISMIC DESIGN OF A RETAINING WALL [PDF]
Proceedings of the 4th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering (COMPDYN 2013), 2014 The design of containment walls suffering seismic loads traditionally has been realized with methods based on pseudoanalitic procedures such as Mononobe-Okabe's method, which it has led in certain occasions to insecure designs, that they have produced the ruin of many containment walls suffering the action of an earthquake. The recommendations gathered
openaire +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source