Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Stimulus-Evoked Brain Signals for Parkinson's Detection: A Comprehensive Benchmark Performance Analysis on Cross-Stimulation and Channel-Wise Experiments. [PDF]
Patel K +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Integrating trunk endurance, dynamic stability, and in-game performance analysis in youth elite basketball players. [PDF]
Gál-Pottyondy A +3 more
europepmc +1 more source
Performance analysis and strategic improvement of logistics operations in a sports retail company
Blasi Cairol, Víctor
openalex +1 more source
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Design and performance analysis of all-dielectric reflective, metalens for LWIR applications. [PDF]
Mukhtar S, Viegas J.
europepmc +1 more source
Identifying urban green space health priorities using asymmetric impact performance analysis in Kangbashi district Ordos China. [PDF]
Yang Y, Zhang J, Gao D, Guo Q, Hao S.
europepmc +1 more source

