Results 31 to 40 of about 871,539 (301)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Novel endoscopic gastric purse-string suture device for weight management in a porcine model (with video)

Endoscopy International Open
Obesity is a global health issue. Traditional treatment modalities such as lifestyle modifications, pharmacological interventions, and bariatric surgery often present various limitations.
Yiyu Qiao, Shuqian Hu, Wei Shen, Airong Tang, Xueting Zhang, Hanqing Zhang, Min Min, Yan Liu   +7 more
doaj   +1 more source

Does the revised cardiac risk index predict cardiac complications following elective lung resection? [PDF]

, 2013
Background: Revised Cardiac Risk Index (RCRI) score and Thoracic Revised Cardiac Risk Index (ThRCRI) score were developed to predict the risks of postoperative major cardiac complications in generic surgical population and thoracic surgery respectively.
A Bobbio, A Brunelli, A Brunelli, A Brunelli, Amy Kerr, Andrea Marshall, AS Detsky, Babu Naidu, CA Polanczyk, CD Parmar, D Amar, DJ Bertges, DW Hosmer, E Lim, Ehab Bishay, HC Fernando, JP Mathew, L Goldman, LA Fleisher, Maninder Kalkat, MK Ferguson, MK Ford, Pala Rajesh, Richard Steyn, Robin Wotton, TH Lee, V Fuster, WD Neary   +27 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Chronic jet lag alters gut microbiome and mycobiome and promotes the progression of MAFLD in HFHFD-fed mice

Frontiers in Microbiology, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide. Circadian disruptors, such as chronic jet lag (CJ), may be new risk factors for MAFLD development.
Ruoyi Zheng, Ruoyi Zheng, Xingwei Xiang, Ying Shi, Anqi Qiu, Xin Luo, Junyan Xie, Ryan Russell, Dongmei Zhang, Dongmei Zhang   +9 more
doaj   +1 more source

Complications of Cerebral Angiography Performed at a University Hospital

JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA, 2018
Objective: The risk of complication of cerebral angiography has always been the focus of attention. The aim of this study was to evaluate the outcome of cerebral angiography performed in the first 30 months of operational training in the endovascular neurosurgery service of a university hospital.
Adriano Torres Antonucci, Paulo Henrique Pires de Aguiar, Damacio Ramón Kaimen-Maciel, Ana Lucia Cruz Fürstenberger Lehmann, Edna Maria Vissoci Reiche, Natally M. Santiago, Marcio Francisco Lehmann, Johnathan de Sousa Parreira   +7 more
openaire   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Predicting diabetes-related hospitalizations based on electronic health records [PDF]

, 2019
OBJECTIVE: To derive a predictive model to identify patients likely to be hospitalized during the following year due to complications attributed to Type II diabetes. METHODS: A variety of supervised machine learning classification methods were tested and
Brisimi, Theodora S., Dai, Wuyang, Paschalidis, Ioannis Ch., Wang, Taiyao, Xu, Tingting   +4 more
core   +1 more source

Complication rates as a trauma care performance indicator: a systematic review [PDF]

Critical Care, 2012
Abstract Introduction Information on complication rates is essential to trauma quality improvement efforts. However, it is unclear which complications are the most clinically relevant. The objective of this study was to evaluate whether there is consensus on the complications that should be used to ...
Lynne Moore, Lynne Moore, Alexis F. Turgeon, Henry T. Stelfox   +3 more
openaire   +3 more sources