Results 51 to 60 of about 483,838 (251)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Outcomes following oesophagectomy in patients with oesophageal cancer: a secondary analysis of the ICNARC Case Mix Programme Database [PDF]

, 2009
Introduction: This report describes the case mix and outcomes of patients with oesophageal cancer admitted to adult critical care units following elective oesophageal surgery in England, Wales and Northern Ireland.
Rowan, KM, Welch, CA, Cromwell, DA, Cromwell, David A., Palser, Thomas R, Perkins, Gavin D., Harrison, David A, Cromwell, David A, Gao Smith, Fang; id_orcid, Rowan, Katherine M., Fang Gao, Welch, Catherine A, Rowan, Katherine M, Palser, Thomas R., Catherine A Welch, Alderson, Derek, Park, Daniel P, Gao, Fang, David A Cromwell, Welch, Catherine A., Perkins, Gavin, Park, Daniel P., Harrison, D. A. (David A.), Katherine M Rowan, Daniel P Park, Harrison, DA, Park, Daniel, Gavin D Perkins, Palser, TR, Perkins, Gavin D, David A Harrison, Smith, F. Gao (Fang Gao), Thomas R Palser, Derek Alderson   +33 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prognostic performance of the neutrophil-lymphocyte ratio for early complications following sleeve gastrectomy [PDF]

Aim: To evaluate the prognostic performance of the preoperative neutrophil-to-lymphocyte ratio (NLR) for early complications following sleeve gastrectomy.
Torres-Pesantes, Luciana, Salinas-Sedo, Gustavo, Rodriguez-Sagastegui, Julio O., Huertas-Campos, Luz F., Toro-Huamanchumo, Carlos J., Pinto-Elera, Jesús   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Vascular complications in high-performance athletes [PDF]

, 2001
Purpose: The purpose of this study was to evaluate our experience with the diagnosis and management of vascular injuries in a group of high-performance athletes.
Harris, E.John, E.John Harris, Zarins, Christopher K., Olcott, Cornelius, Christopher K. Zarins, Cornelius Olcott, Arko, Frank R., Frank R. Arko   +7 more
core   +1 more source

Thermal changes in guidewires used during endoscopic retrograde cholangiopancreatography during electrical conductance: Ex-vivo safety experiment

Endoscopy International Open
Risks of pancreaticobiliary tissue damage secondary to electrical conduction along cannulation wires in the vicinity of electrocautery have rarely been independently studied and remain mostly a theoretical issue.
Rahul Karna, Nicholas M McDonald, Jacob Weiner, Théodon I Netoff, Stuart K Amateau   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Regression model of health worker performance during intrapartum care simulation (preterm delivery with complications).

, 2017
Regression model of health worker performance during intrapartum care simulation (preterm delivery with complications).
Lolade Oseni (3841621), Tambudzai Rashidi (3841618), Barbara Rawlins (410157), Shivam Gupta (600768), Fannie Kachale (3841615), Naoko Kozuki (538713), Reena Sethi (3841627), Angella Mtimuni (3841624)   +7 more
core   +1 more source