Results 61 to 70 of about 483,838 (251)

A stag beetle knife can achieve stabler and safer endoscopic submucosal dissection in the esophagus

Endoscopy International Open, 2023
Kohei Funasaka, Noriyuki Horiguchi, Hyuga Yamada, Keishi Koyama, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Eizaburo Ohno, Teiiji Kuzuya, Ryoji Miyahara, Tomoyuki Shibata, Yoshiki Hirooka   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Grading static versus dynamic images of contact lens complications

, 2007
BACKGROUND: This study was conducted to investigate grading performance when estimating the severity of static versus dynamic images of contact lens-related ocular pathology.
Chaudry, Aysha, Nathan Efron, Efron, Nathan, Aysha Chaudry   +3 more
core   +1 more source

Performance of the early warning system score in predicting postoperative complications in older versus younger patients [PDF]

Background Early warning system (EWS) scores are implemented on surgical wards to identify patients at high risk of postoperative clinical deterioration, but its predictive value in older patients is unclear.
Hollmann, Markus W., Werger, A., Boer, Christa, Wensing, A. G. C. L., Jwair, A., van Roy, J. P., Posthuma, Linda M., van Gorp, R., Vernooij, Lisette, Breel, J. S., Koca, F., Geurts, J., Stolze, Annick, Buhre, Wolfgang F. F. A., van Dijk, F., Glas, W., Rinia, Myra, Smit-Fun, Valerie M., Preckel, B., Hering, Jens-Peter, Noordzij, Peter G., Theunissen, M., in't Veld, Bas, de Korte-de Boer, Dianne, Bouw, T., van Kuijk, Sander, Lange, I, Scheffer, Gert-Jan   +27 more
core   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Multifactorial determinants of complications and patient-reported outcomes in metal clasp-retained removable partial dentures [PDF]

PURPOSE. This cross-sectional study aimed to evaluate the distribution of complications in clasp-retained removable partial dentures (C-RPDs) and to investigate the influence of denture design parameters, denture age, and Kennedy and Eichner ...
Bilgen, Berk, Kaffaf, Berk, Şakar, Olcay   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source