Results 231 to 240 of about 26,857,718 (311)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Subject-Specific Deep Learning Model for Motor Imagery Direction Decoding. [PDF]

Sensors (Basel)
Parashiva PK, Kutteri SG, Vinod AP.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Developing Midlife Metacognitive Strategy Training (M-MCST) program: A feasibility study with middle-aged adults to evaluate the design, implementation, and impact of a novel program in fostering healthy cognitive aging. [PDF]

PLoS One
Rooha A, Swamy S, Jacob NL, Bajaj G, Chaudhary C, George VM, Bhat JS.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Intrinsic Plasticity-Driven Neuroadaptive Asymptotic Tracking Control for a Class of Uncertain Robotic Manipulators. [PDF]

Sensors (Basel)
Chen Q, Tan X, Hou S, Qing M, Li Z.
europepmc   +1 more source

Multi-Source Perception, Intelligent Decision-Making, and Precision Control for Autonomous Agricultural Systems: A Comprehensive Review. [PDF]

Sensors (Basel)
Zhang S, Zhu Y, Zhao Z, Xu J, Zhang J, Zheng Z.   +5 more
europepmc   +1 more source

A Muscle Fiber-Based Soft Hand Exoskeleton Control Strategy for Fine Manipulation: A Preliminary Investigation. [PDF]

Biomimetics (Basel)
Yang J, Zhang C, Li N, Wen J, Yang W, Chen W.   +5 more
europepmc   +1 more source

Duration-dependent acute effects of foam rolling on dominant-hand visual reaction time in male youth basketball players: A randomized controlled study. [PDF]

PLoS One
Altınçekiç KS, Çelen Ş, Coşkun O, Avcı S, Baikoğlu SB, Özağır M, Dal S, Akkoç O.   +7 more
europepmc   +1 more source