Results 121 to 130 of about 3,037,170 (287)

A first--order irreversible thermodynamic approach to a simple energy converter

open access: yes, 2007
Several authors have shown that dissipative thermal cycle models based on Finite-Time Thermodynamics exhibit loop-shaped curves of power output versus efficiency, such as it occurs with actual dissipative thermal engines.
A. L. Lehninger   +16 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Revisiting the Old Industrial Region: Adaptation and Adjustment in an Integrating Europe [PDF]

open access: yes, 2006
The position of old industrial regions (OIRs) has been neglected in recent regional development research, partly as a result of dominant discourses concerned with concepts such as the knowledge economy, learning regions and the new regionalism.
Birch, Kean   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A reasonable benchmarking frontier using DEA : an incentive scheme to improve efficiency in public hospitals [PDF]

open access: yes, 2007
There exists research relating management concepts with productivity measurement methods that offers useful solutions for improving management control in the public sector.
Prior, Diego, Surroca, Jordi
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Performance and efficiency in Colombia's power utilities: an assessment of the 1994 reform [PDF]

open access: yes
This paper describes the core features of the power sector 1994 regulatory reform and evaluates utility performance and efficiency before and after the reform.
Carlos Pombo, Rodrigo Taborda
core  

Mediation Effect of Lean: A Bidirectional Synergetic Relationship with SCM for Higher Operational Performance [PDF]

open access: yes, 2018
Competitive plants focus their efforts on reducing manufacturing costs and waste along their production chains. Hence, manufacturing programs with important practices and methodologies such as lean, JIT, TPM, and Kaizen have been embraced.
Acevedo Amaya, Mario Roberto   +2 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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