Results 31 to 40 of about 70,536 (266)
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Optimising breeding performance in a seriously endangered species such as the black rhinoceros (Diceros bicornis) is essential. Following an estimation of the population demography of the black rhinos in Solio Game Reserve, Kenya and a habitat ...
Felix Patton +2 more
doaj +1 more source
Les variations saisonnières des performances de reproduction chez la truie
Bien que la truie ne connaisse pas d’anœstrus saisonnier, une diminution des performances de reproduction est observée en été et au début de l’automne dans de nombreux pays. La proportion de truies qui tardent à revenir en oestrus après le tarissement augmente tandis que la proportion de truies inséminées qui mettent bas baisse de 5 à 15 %.
Quesnel, Helene +2 more
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
L’objectif de cette étude était d’évaluer l’effet du croisement alternatif sur les performances reproductives et la productivité des ovins. Deux races ovines indigènes algériennes ont été utilisées : Ouled Djellal (OD), connue pour ses qualités ...
Kahina Sebkhi +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Le troupeau de chèvres rousses d'un village de la région de Maradi a été observé pendant trois années consécutives. Les résultats enregistrés ont permis de préciser quelques aspects de la reproduction chez cette race: répartition des mises bas, âge à la ...
J.B. Haumesser
doaj +1 more source
L’étude a été menée à l’ouest de la Côte d’Ivoire dans le district des Montagnes sur 120 vaches et 96 veaux mâles et femelles de races N’Dama et croisées (Montbéliarde x N’Dama) pendant 36 mois afin de déterminer leurs performances de reproduction et de
Nicolas Bosson Aboly +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

