Results 111 to 120 of about 9,772,737 (279)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Hospital performance: costs of acute admitted patients in public hospitals in 2011–12 [PDF]

, 2015
Some public hospitals spend nearly twice as much money as others to provide similar services to similar groups of patients. Overview Hospitals account for a large share of the funds Australia spends on the health sector each year. In 2011–12, about 30%
National Health Performance Authority
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prevalence of prescription and over-the-counter drug misuse for performance enhancement in Jordanian gyms: a cross-sectional study

Future Journal of Pharmaceutical Sciences
Background The non-sporting gym-goers are also turning to the use of performance-enhancing substances (PES) without medical guidance; according to recent statistics within the Middle East, there is also a rising pattern of abuse.
Leena Ahmad, Anas Khaleel, Saba Alshatali, Omar Salim Dahbour, Yazan Ahmad Abdelaziz, Ahmad Al Athamneh   +5 more
doaj   +1 more source

„Brain doping” substances: prohibited or not in sports?

Biology of Sport
There is increasing interest in the area of brain doping among athletes. The term ‘brain doping’ refers to enhancing mental performance through the non-medical use of specific pharmacological substances, such as drugs and medicines.
Andrzej Pokrywka, Olga Surała, Konstancja Grabowska, Marta Przybyła, Dominika Granda, Andrzej Małecki, Raphael Faiss, Marta Nowacka-Chmielewska   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Caffeine and anaerobic. DOI: http://dx.doi.org/10.5007/1980-0037.2012v14n5p602

Revista Brasileira de Cineantropometria e Desempenho Humano, 2012
The ergogenic effect of caffeine on anaerobic exercises remains controversial. Such effect seems to depend on exercise duration, test protocol, and training status of the subjects studied.
Bruno Honorato da Silveira, Rafael Alves de Aguiar, Tiago Turnes, Fabrizio Caputo   +3 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Drug abuse in athletes

Substance Abuse and Rehabilitation, 2014
Claudia L Reardon, Shane Creado Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Abstract: Drug abuse occurs in all sports and at most levels of competition.
Reardon CL, Creado S
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source