Results 231 to 240 of about 3,925,092 (294)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

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Indexing Esport Performance

Journal of Electronic Gaming and Esports, 2023
The assessment of an athlete’s performance can play a key role in determining their current state, their readiness to compete, the impact of an experimental manipulation, and/or the influence of an intervention. At present, there is limited empirical evidence stating the indicators that encapsulate individual performance within any esport.
Sharpe, Benjamin, Besombes, Nicolas, Welsh, Matthew, Birch, Phil   +3 more
openaire   +2 more sources

Are 'Indexes' an Index of Physician Performance?

Archives of Internal Medicine, 1985
In this issue of theArchives, Hansen and associates 1 present data from a chart audit reflecting physician behavior in the interpretation of RBC indexes. The authors begin with the fact that patients having low mean RBC volumes and high RBC counts relative to those volumes will commonly be found to have thalassemic syndromes if properly examined ...
openaire   +2 more sources

Glycaemic Index and Optimal Performance

Sports Medicine, 1997
It is widely documented that athletes should consume carbohydrates prior to, during and after exercise. Ingestion of carbohydrates at these times will optimise performance and recovery. In spite of this knowledge, there is a paucity of information available to athletes concerning the types of carbohydrate foods to select.
P, Walton, E C, Rhodes
openaire   +2 more sources

[Myocardial performance index].

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2008
Myocardial performance index (MPI) is a numeric value, which could be obtained by using cardiac time intervals. This numeric value is defined as the sum of isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) divided by ejection time (ET) and could be calculated for each ventricle individually.
Abdullah, Uluçay, Ersan, Tatli
openaire   +3 more sources

Glycemic Index and Endurance Performance

International Journal of Sport Nutrition and Exercise Metabolism, 2010
The aim of this review is to provide an up-to-date summary of the evidence surrounding glycemic index (GI) and endurance performance. Athletes are commonly instructed to consume low-GI (LGI) carbohydrate (CHO) before exercise, but this recommendation appears to be based on the results of only a few studies, whereas others have found that the GI of CHO ...
Carolyn M, Donaldson, Tracy L, Perry, Meredith C, Rose   +2 more
openaire   +2 more sources

An Index of Hospital Performance

Medical Care, 1978
The purpose of this paper is to describe a simple index for computing relative hospital performance. An analysis of 33 short-stay general hospitals in New South Wales was used to develop the index. The index is based on patterns of admissions for each hospital, adjusting the hospital's crude death rate for the age distribution of patients treated and ...
S J, Duckett, S M, Kristofferson
openaire   +2 more sources