Results 61 to 70 of about 1,137,377 (219)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Formation of highly intelligent capital at the expense of government spending: Economic effect for Kazakhstan [PDF]

Knowledge & Performance Management
Type of the article: Research Article Support for the education system is a strategic measure that ensures the long-term development and growth of a country’s economy.
Dana Kangalakova, Olzhas Adilkhanov, Dinara Mukhiyayeva, Sharbanu Turdalina, Zaira Satpayeva   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Determinants of lecturer quality in Vietnamese public universities: Evidence from a quantitative assessment aligned with AUN-QA standards [PDF]

Knowledge & Performance Management
Type of the article: Research Article This study investigates the influence of institutional and individual factors on lecturer quality within Vietnamese public universities under the AUN-QA framework. A quantitative cross-sectional survey was conducted
Thi Thu Phuong Do, The Tuan Tran, Nguyen Thi Diep   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Lecturers’ financial well-being: The mediating role of financial literacy in Southwest Papua, Indonesia [PDF]

Knowledge & Performance Management
Type of the article: Research Article Lecturers’ financial well-being is an important factor influencing work motivation, teaching quality, and professional commitment in implementing the Tri Dharma of Higher Education.
Rokhimah, Triyonowati, Suhermin
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The mediating effects of work motivation and organizational support on the relationship between knowledge management and environmental law knowledge in Vietnamese commercial banks [PDF]

Knowledge & Performance Management
Type of the article: Research Article This study examines whether knowledge management practices in commercial banks influence employees’ knowledge of environmental law, providing empirical evidence from Vietnam’s banking sector as an emerging Asian ...
Ha Nguyen Son, Hai Phan Thanh
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

From digital canvas learning to economic growth: The human capital pathway in entrepreneurial universities [PDF]

Knowledge & Performance Management
Type of the article: Research Article Despite the rapid digital transformation in higher education, empirical evidence explaining how digital entrepreneurship learning contributes to human capital formation, entrepreneurial universities, and economic ...
Zulkifli Sultan, Eka Pariyanti, Afiah Mukhtar, Dewi Tri Komalasari   +3 more
doaj   +1 more source