Results 101 to 110 of about 26,183,516 (287)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Data fusion for timber bundle volume measurement

, 2019
In many industrial fields, the direct measurement of a specific parameter of interest can be too costly to be feasible. Using data from other parameters about the process, a data driven approach can instead be used for a cost-efficient estimation of the ...
Liguori C., O'Nils M., Pietrosanto A., Carratu M., Lundgren J.   +4 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Adoption of the performance measurement system in the Nigerian public sector: Challenges and prospects [PDF]

, 2015
Assessing the performance of organizations using the performance measurement system has gradually become a common practice in the public sector entities.This has been established to be a direct fall out of the ripple effect of the new public management ...
Abubakar, Abdulkadir, Saidin, Siti Zabedah, Ahmi, Aidi   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Performance Measurement System in Islamic Bank: Some Issues and Considerations

Jurnal Akuntansi Multiparadigma, 2010
There are various evidences show that business that complied with Islamic laws, i.e. Islamic business has succeeded. Islamic bank is the most prominent model of Islamic business that is acknowledged widely which could be proven by its existence in many ...
Noval Adib, Siti-Nabiha Abdul Khalid
doaj  

Evaluating supply chain performance measurement system (SCPMS) lifecycle during unexpected events

Production and Manufacturing Research: An Open Access Journal
Supply chain management is recognized as a crucial element in boosting organizational performance and competitiveness. However, the COVID-19 crisis has demonstrated that many corporations were unprepared and lacked a recovery strategy, which led to ...
Nevien Khourshed, Mahmoud Beshr
doaj   +1 more source

Fuzzy Performance Measurement System for the Maintenance Function

MATEC Web of Conferences, 2018
Maintenance aims to sustain the manufacturing process by ensuring that the production tools are well managed. However, modern production means are more automated and therefore more complex, so they require a performing maintenance for which planning and ...
Naji Mehdi Amine, Mousrij Ahmed
doaj   +1 more source