Results 101 to 110 of about 27,966,819 (292)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The benefits of an e-business performance measurement system

, 2010
This chapter investigates how organizations have been adapting their performance measurement practices in response to their adoption of e-business in their business operations.
Hinton, M., Hinton, Matthew, Barnes, D., David Barnes, Barnes, David, Matthew Hinton   +5 more
core   +1 more source

Logistics performance measurement system for the automotive industry

Logistics Research, 2016
Logistics can be seen as a key competitive factor in the automotive industry due to the rising number of model variants and options. With the increasing importance of logistics (Gunasekaran et al.
Martin Dörnhöfer, Falk Schröder, Willibald A. Günthner   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Low-overhead end-to-end performance measurement for next generation networks [PDF]

, 2011
Internet performance measurement is commonly perceived as a high-cost control-plane activity and until now it has tended to be implemented on top of the network’s forwarding operation.
Hutchison, D., David Hutchison, Hoerdt, M., Pezaros, Dimitrios, Mickaël Hoerdt, Hoerdt, Mickael, Hutchison, David, Pezaros, D.P., Dimitrios P Pezaros   +8 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Integrating Digital Transformation with Sustainability: How to Define a Net-Zero Performance Measurement System [PDF]

Climate change presents an urgent global crisis with significant implications across all regions and sectors and the need for concerted efforts to mitigate its effects and transition towards a net-zero emission society is one of the key challenges of our
Gallotta, B., Daniel, J., Hourneaux, F.
core  

Evaluating supply chain performance measurement system (SCPMS) lifecycle during unexpected events

Production and Manufacturing Research: An Open Access Journal
Supply chain management is recognized as a crucial element in boosting organizational performance and competitiveness. However, the COVID-19 crisis has demonstrated that many corporations were unprepared and lacked a recovery strategy, which led to ...
Nevien Khourshed, Mahmoud Beshr
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source