Results 121 to 130 of about 26,183,516 (287)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Influence of Management Accounting Information, Performance Measurement System, and Reward System On Managerial Performance In Modern Retail Companies In Cirebon City

International Journal of Islamic Education, Research and Multiculturalism
This study aims to determine the effect of the application of accounting information, performance measurement systems and reward systems to managerial performance in modern retail companies in Cirebon City.
Roni Mulyatno, Rahmawati Mulyasari Dewi, Rismawati Rismawati, Riqzma Nur Warsya   +3 more
doaj   +1 more source

Performance measurement systems : auditing and prioritisation of performance measures

, 1998
Identifying and prioritising performance measures are common problems faced by most companies. This paper presents the works at University of Strathclyde to address these issues. First, Integrated Performance Measurement System Reference Model, and then the Quantitative Model for Performance Measurement System (IPMS) is introduced.
Suwignjo, P., Bititci, Umit, Carrie, Allan, Turner, Trevor   +3 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

THE CURRENT AND PROBLEM OF PERFORMANCE MEASUREMENT [PDF]

, 1999
The executive (fox) seizing great power with his accomplice (bear) and desires to keep on seizing his power is beginning to adopt performance measurement. Performance measurement is a means of the administrative reform.
HIRAOKA, Naoto, 平岡, 直人, WAKAYAMA, Hiroshi, ワカヤマ, ヒロシ, ヒラオカ, ナオト, 若山, 浩司   +5 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A Mixed-Methods Evaluation of the Implementation of a Performance Measurement System for South Africa's Substance Use Treatment Services. [PDF]

J Stud Alcohol Drugs Suppl, 2019
Myers B, Williams PP, Govender R, Manderscheid R, Koch JR.   +4 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source