Results 121 to 130 of about 1,214,931 (316)
Using Weighted Data Envelopment Analysis to Measure Occupational Safety and Healthy Economic Performance of Taiwan’s Industrial Sectors [PDF]
Li‐Ting Yeh
openalex +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Arturs Zemitis,1,2 Vincenzo Rizzuto,1– 4 Diana Lavrinovica,1,2 Juris Vanags,1,2 Guna Laganovska1,2 1Riga Stradins University, Department of Ophthalmology, Riga, Latvia; 2Pauls Stradins Clinical University Hospital, Clinic of Ophthalmology, Riga, Latvia ...
Zemitis A +4 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Sistem pengukuran kinerja manajemen yang menggabungkan ukuran-ukuran keuangan dan non keuangan menurut Kaplan dan Norton disebut: Balanced Scorecard (BSC). Tujuan sistem pengukuran kinerja ini adalah membantu mengimplementasikan strategi dan penggunaan pengendalian interaktif dalam mengembangkan strategi-strategi baru.
Wouter Van Dooren +2 more
openaire +2 more sources
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Comparative Performance of Bayesian and AIC-Based Measures of Phylogenetic Model Uncertainty [PDF]
Michael E. Alfaro, John P. Huelsenbeck
openalex +1 more source

