Results 141 to 150 of about 12,134,415 (311)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Determination of selenium in sea water using electron capture detection-gas chromatography.
, 1977 A method has been developed for the determination of selenium IV and total selenium in natural waters. It involves the formation of the derivative of seleriiuic 1V with 4-nit:-o-c-phersylenediamine at pH i, extraction into toluene and dLteraination by ...
Measures, Christopher Ian
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Sparse Multi-View K-Means Clustering
IEEE AccessIn machine learning, k-means clustering is an unsupervised leaning technique to partition the data into k clusters that are homogeneous within the cluster and heterogeneous between clusters.
Miin-Shen Yang, Shazia Parveen
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discretion and Bias in Performance Evaluation: The Impact of Diversity and Subjectivity [PDF]
In this paper, I use a proprietary archival data set of one firm to examine the impact of performance measure diversity and the use of subjective performance measures on performance evaluation bias.
Moers,Frank
core
Healthy communities: frequent GP attenders and their use of health services in 2012–13 [PDF]
, 2015 More than one-third of Australians (35.3%) went to a GP six or more times in 2012–13, and those who went most often tended to be older and less wealthy, were more likely to have several long-term health conditions and were more likely to see several ...
National Health Performance Authority
core
IEEE AccessThe Inverse Gaussian distribution (IGD) is a probability distribution with several applications in various fields. The proposed study is prone to consider the problem of monitoring the shape parameter of IGD using the Bayesian method.
Tahir Abbas +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source