Results 161 to 170 of about 12,134,415 (311)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Measures Vs. Actions: The Balanced Scorecard in Swedish Law Enforcement [PDF]

(WP 12/03 Clave pdf) Our investigation drew upon the deployment of the balanced scorecard in Swedish Law Enforcement, an organization that long ago implemented the new paradigm of policing, which consisted in enhancing the quality of urban life on the ...
SALVADOR CARMONA
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

When Metrics Replace Values: Ethical Concerns in Healthcare Performance Measures. [PDF]

Acad Emerg Med
Chhabra N.
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Genome‐Wide Pleiotropy Analysis of Longitudinal Blood Pressure and Harmonized Cognitive Performance Measures [PDF]

Alzheimers Dement
Kang M, Ang T, Devine S, Sherva R, Mukherjee S, Trittschuh E, Gibbons L, Scollard P, Lee M, Choi S, Klinedinst B, Nakano C, Dumitrescu L, Hohman T, Cuccaro M, Saykin A, Kukull W, Bennett D, Wang L, Mayeux R, Haines J, Pericak‐Vance M, Schellenberg G, Crane P, Au R, Lunetta K, Mez J, Farrer L.   +27 more
europepmc   +2 more sources

From audit to policy: ESGE performance measures in centralized device-assisted enteroscopy services. [PDF]

Endosc Int Open
Wurm Johansson G, Koulaouzidis A, Toth E.   +2 more
europepmc   +1 more source

Measuring and improving performance [PDF]

Journal of Health Services Research & Policy, 2016
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Performance measures across playing categories in competitive golfers with disabilities: a cross-sectional study. [PDF]

Front Sports Act Living
Jones KM, Wynter Bee W, Stenner B, Hawkes R, Wallace ES.   +4 more
europepmc   +1 more source