Results 91 to 100 of about 2,298,006 (288)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Software Defined Radio Implementation of Non-Orthogonal Multiple Access with Reliable Decoding via Error Correction

Future Internet
Non-orthogonal multiple access (NOMA) has been identified as one of the key technologies for 6G capacity and latency gains. However, existing implementation challenges of the NOMA technique, related to carrier, timing, and phase offsets, successive ...
Dipanjan Adhikary, Eirini Eleni Tsiropoulou   +1 more
doaj   +1 more source

Performance optimization of parallel algorithms

Journal of Communications and Networks, 2014
The high intensity of research and modeling in fields of mathematics, physics, biology and chemistry requires new com- puting resources. For the big computational complexity of such tasks computing time is large and costly. The most efficient w ay to increase efficiency is to adopt parallel principles.
Martin Hudik, Michal Hodon
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Multi-task interference during walking in children, adolescents and young adults

Scientific Reports
This study aimed to investigate the effects of dual task (DT) and triple task (TT) conditions on walking performance in male children, adolescents and young adults.
Rabeb Laatar, Rihab Borji, Mohamed Achraf Harrabi, Wissal boughattas, Haithem Rebai, Sonia Sahli   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effects of home-based slow-paced breathing on functional performance in middle-aged women: A randomized controlled trial study

Experimental Gerontology
As individuals age, functional performance declines, particularly affecting mobility, strength, and postural balance, with middle-aged women experiencing earlier and more pronounced impairments due to menopausal transition.
Karama Masmoudi, Fatma Chaari, Haithem Rebai, Sonia Sahli   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Chest wall restriction device for modeling respiratory challenges and dysfunction

Frontiers in Medical Engineering
Breathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues, Lizuannette Mejia, Rafael G. Zucchi, Paul W. Davenport, Nicholas J. Napoli   +4 more
doaj   +1 more source