Results 101 to 110 of about 10,311,340 (298)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Performance optimization algorithm of radar signal processing system

, 2017
A performance optimization algorithm of radar signal processing system is proposed. Based on a new modeling mode of radar signal processing system, the values of performance indexes of radar system can be predicted by a performance prediction method ...
Du JS(杜劲松), Li X(李想)
core  

Multi-skill resource-constrained project scheduling problem: a case study in an open-pit mining process

In this article, a case study is analysed using an adaptation of a project scheduling problem with multitasking resource restrictions. The objective is to reduce the operational costs of an open-pit mining process that uses mobile surface equipment, by ...
Solano-Charris E.L., Wiest-Goyeneche J.R., Vega-Mejía C.A.   +2 more
core   +1 more source

Chest wall restriction device for modeling respiratory challenges and dysfunction

Frontiers in Medical Engineering
Breathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues, Lizuannette Mejia, Rafael G. Zucchi, Paul W. Davenport, Nicholas J. Napoli   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Incremental evolution strategy for function optimization [PDF]

, 2006
This paper presents a novel evolutionary approach for function optimization Incremental Evolution Strategy (IES). Two strategies are proposed. One is to evolve the input variables incrementally.
Mo, W, Guan, SU
core   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Importance of Positive Attitudes Toward Disability Among Future Health and Education Professionals: A Comparative Study

Education Sciences
Understanding and embracing positive attitudes toward disability are crucial for inclusive practices. Universities play a key role in shaping these attitudes, making higher education critical for promoting inclusion and understanding diversity.
Luisa Gámez-Calvo, Jesús Muñoz-Jiménez, Margarita Gozalo   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Performance

Representing the output of the research project "Performance: Conservation, Materiality, Knowledge," this volume brings together diverse voices, methods, and formats in the discussion and practice of performance conservation.

core   +1 more source