Results 11 to 20 of about 22,850 (146)

Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways

Advances in Pharmacological Sciences, 2014
Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method. Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric
Amang André Perfusion, Paul V. Tan, Nkwengoua Ernestine, Nyasse Barthélemy   +3 more
doaj   +1 more source

Gammagrafía de la perfusión cerebral

Oncología, 2022
Se comentan en este artículo aspectos importantes de la Gammagrafía de perfusión cerebral, y sus diversas aplicaciones clínicas en las enfermedades neurológicas. Se enfoca además la utilidad de la Tomografía por emisión de fotón único (SPECT) Cerebral y
Silvia Vázquez
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Cardiopulmonary bypass for total aortic arch replacement surgery: A review of three techniques

Frontiers in Cardiovascular Medicine, 2023
One treatment for acute type A aortic dissection is to replace the ascending aorta and aortic arch with a graft during circulatory arrest of the lower body, but this is associated with high mortality and morbidity.
Ying Cui, Xinhao Liu, Jiyue Xiong, Zhaoxia Tan, Lei Du, Jing Lin   +5 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Empleo de bypass parcial izquierdo para corrección de coartación de aorta: ¿cuándo, cómo y por qué?

Cirugía Cardiovascular, 2017
La reparación de la coartación de aorta presenta actualmente una morbimortalidad inferior al 1-2%. En su mayoría, se realiza durante el período neonatal debido a un diagnóstico precoz.
María-Teresa González-López, Juan-Miguel Gil-Jaurena, José-Ángel Zamorano-Serrano, Irene Hidalgo-García, Ana-María Pita-Fernández, Ramón Pérez-Caballero-Martínez   +5 more
doaj   +1 more source

Effects of Steroid Hormones on Sex Differences in Cerebral Perfusion. [PDF]

PLoS ONE, 2015
Sex differences in the brain appear to play an important role in the prevalence and progression of various neuropsychiatric disorders, but to date little is known about the cerebral mechanisms underlying these differences.
Carmen Ghisleni, Steffen Bollmann, Anna Biason-Lauber, Simon-Shlomo Poil, Daniel Brandeis, Ernst Martin, Lars Michels, Martin Hersberger, John Suckling, Peter Klaver, Ruth L O'Gorman   +10 more
doaj   +1 more source