Results 21 to 30 of about 824,468 (289)

An integrated perfusion machine preserves injured human livers for 1 week

Nature Biotechnology, 2020
The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation.
D. Eshmuminov, Dustin Becker, Lucia Bautista Borrego, M. Hefti, M. Schuler, Catherine Hagedorn, X. Muller, Matteo Mueller, C. Onder, R. Graf, A. Weber, P. Dutkowski, P. Rudolf von Rohr, P. Clavien   +13 more
semanticscholar   +1 more source

Review of Perfusion Imaging in Acute Ischemic Stroke: From Time to Tissue.

Stroke, 2020
Perfusion imaging uses an intravascular tracer and serial imaging to quantify blood flow through the brain parenchyma. In acute ischemic stroke, perfusion imaging may increase diagnostic accuracy, aid treatment target identification, and provide ...
J. Demeestere, A. Wouters, S. Christensen, R. Lemmens, M. Lansberg   +4 more
semanticscholar   +1 more source

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

EBioMedicine, 2020
Background Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant ...
A. Schlegel, X. Muller, Matteo Mueller, Anna Stepanova, P. Kron, O. de Rougemont, P. Muiesan, P. Clavien, A. Galkin, D. Meierhofer, P. Dutkowski   +10 more
semanticscholar   +1 more source

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

New England Journal of Medicine, 2019
Background The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited to within 4.5 hours after the onset of symptoms.
Henry Ma, B. Campbell, M. Parsons, L. Churilov, C. Levi, Chung Y. Hsu, T. Kleinig, T. Wijeratne, Sami Curtze, H. Dewey, F. Miteff, C. Tsai, Jiunn‐Tay Lee, T. Phan, N. Mahant, Mu-Chien Sun, M. Krause, J. Sturm, R. Grimley, Chih-Hung Chen, Chaur-Jong Hu, A. Wong, D. Field, Yu Sun, P. Barber, A. Sabet, J. Jannes, J. Jeng, B. Clissold, R. Markus, Ching-Huang Lin, L. Lien, C. Bladin, S. Christensen, N. Yassi, G. Sharma, A. Bivard, P. Desmond, B. Yan, P. Mitchell, V. Thijs, L. Carey, A. Meretoja, S. Davis, G. Donnan   +44 more
semanticscholar   +1 more source

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic ...
G. Hernández, G. Ospina-Tascón, L. Damiani, E. Estenssoro, A. Dubin, J. Hurtado, G. Friedman, R. Castro, L. Alegría, J. Teboul, M. Cecconi, Giorgio Ferri, M. Jibaja, Ronald Pairumani, P. Fernández, D. Barahona, Vladimir Granda-Luna, A. Cavalcanti, J. Bakker   +18 more
semanticscholar   +1 more source

The Prognostic Significance of Quantitative Myocardial Perfusion

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Myocardial perfusion reflects the macro- and microvascular coronary circulation.
K. Knott, A. Seraphim, J. Augusto, H. Xue, L. Chacko, N. Aung, Steffen Erhard Petersen, J. Cooper, C. Manisty, A. Bhuva, T. Kotecha, C. Bourantas, R. Davies, L. Brown, S. Plein, M. Fontana, P. Kellman, J. Moon   +17 more
semanticscholar   +1 more source

Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal

American Journal of Transplantation, 2020
There is international variability in the determination of death. Death in donation after circulatory death (DCD) can be defined by the permanent cessation of brain circulation.
A. Manara, S. Shemie, S. Large, A. Healey, Andrew J. Baker, M. Badiwala, M. Berman, A. Butler, P. Chaudhury, J. Dark, J. Forsythe, D. Freed, D. Gardiner, D. Harvey, L. Hornby, J. Maclean, S. Messer, G. Oniscu, C. Simpson, J. Teitelbaum, Sylvia Torrance, Lindsay C. Wilson, C. Watson   +22 more
semanticscholar   +1 more source

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

Nature Communications, 2020
Astrocytes provide neurons with essential metabolic and structural support, modulate neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to sense conditions of potential metabolic insufficiency. Here we show that
N. Marina, Isabel N. Christie, A. Korsak, M. Doronin, Alexey R. Brazhe, P. Hosford, J. Wells, S. Sheikhbahaei, I. Humoud, J. Paton, M. Lythgoe, Alexey Semyanov, S. Kasparov, A. Gourine   +13 more
semanticscholar   +1 more source

Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways

Advances in Pharmacological Sciences, 2014
Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method. Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric
Amang André Perfusion, Paul V. Tan, Nkwengoua Ernestine, Nyasse Barthélemy   +3 more
doaj   +1 more source

Modeling lung perfusion abnormalities to explain early COVID-19 hypoxemia

Nature Communications, 2020
Early stages of the novel coronavirus disease (COVID-19) are associated with silent hypoxia and poor oxygenation despite relatively minor parenchymal involvement.
J. Herrmann, V. Mori, J. Bates, B. Suki
semanticscholar   +1 more source