Results 91 to 100 of about 497,841 (322)

Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures

open access: yesAdvanced Healthcare Materials, EarlyView.
The use of organ‐on‐a‐chip (OOC) microfluidic platforms is expanding in biomedical research. While this emerging technology is becoming increasingly accessible, the stability of long‐term functional cultures remains a critical challenge to address. This study presents a straightforward, one‐step method for the functionalization of polydimethylsiloxane ...
Mitzi Pérez‐Calixto   +7 more
wiley   +1 more source

Ensemble Kalman Filters for reliability estimation in perfusion inference [PDF]

open access: yesarXiv, 2018
We consider the solution of inverse problems in dynamic contrast-enhanced imaging by means of Ensemble Kalman Filters. Our quantity of interest is blood perfusion, i.e. blood flow rates in tissue. While existing approaches to compute blood perfusion parameters for given time series of radiological measurements mainly rely on deterministic ...
arxiv  

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

open access: yesAdvanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner   +5 more
wiley   +1 more source

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu   +5 more
wiley   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

open access: yesAdvanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin   +15 more
wiley   +1 more source

A narrative review on miniaturized extracorporeal technology and circuits: a revolutionary approach to cardiac surgery

open access: yesThe Cardiothoracic Surgeon
Background The development of the cardiopulmonary bypass machine for extracorporeal circulation by Dr. John Gibbon marked a significant milestone in the advancement of medical technology.
Trasha Shetty   +2 more
doaj   +1 more source

Limiting the gamble: Risk and predictability for renal replacement therapy in patients receiving mechanical circulatory support★

open access: yesThe Journal of ExtraCorporeal Technology
Background: Patients receiving mechanical circulatory support (MCS) frequently require renal replacement therapy (RRT). Examining risk factors for requiring RRT in patients receiving MCS may allow improved understanding of these comorbidities and enhance
Gore Kelsey   +8 more
doaj   +1 more source

Evaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI

open access: yesTürk Nöroloji Dergisi, 2013
OBJECTIVE: The purpose of this study is to determine the ischemic lesions throughout the brain parenchyma with magnetic resonance imaging (MR) diffusion technique, evaluate vascular architecture and possible abnormalities with MR perfusion technique in ...
Ali Kemal Erdemoglu   +2 more
doaj   +1 more source

Normothermic Perfusion is Superior to Cold Perfusion in Porcine Ex Situ Lung Perfusion

open access: yesTransplantation Proceedings
Cold ex situ lung perfusion (ESLP) has demonstrated improved preservation in small animal ESLP compared to normothermic ESLP and cold static preservation. We hypothesized that cold negative pressure ventilation (NPV)-ESLP would improve graft function in a porcine transplantation model.Four perfusate temperatures were examined with 12 hours NPV-ESLP in ...
Keir Forgie   +11 more
openaire   +2 more sources

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