Results 41 to 50 of about 9,619 (252)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Correlation of perfusion index change and analgesic efficacy in transforaminal steroid injection for lumbosacral pain, a prospective observational study

Saudi Journal of Anaesthesia
Background and Aims: Low back pain is a common problem and a major burden to society. Transforaminal epidural steroid injection is one of the most effective treatment modalities for back pain.
Heley Gatorwala, Ananda Bangera
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hemodialysis-induced renal perfusion decline: unraveling the pathophysiological mechanisms linking intradialytic circulatory stress to residual renal function loss

Frontiers in Pharmacology
BackgroundResidual renal function (RRF) plays a critical role in quality of life and survival in hemodialysis (HD) patients but characteristically declines after the initiation of HD.
Dayang Xie, Jiaming Tan, Qingtao Zhang, Qian Yu, Yiqin Wang, Yujin Wang, Li Gao, Liyuan Yan, Jianhui Zhou, Nan Li, Guangyan Cai   +10 more
doaj   +1 more source

Perfusion index versus non-invasive hemodynamic parameters during insertion of i-gel, classic laryngeal mask airway and endotracheal tube

Indian Journal of Anaesthesia, 2013
Background: Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion obtained from a pulse oximeter. In this study, we evaluated the efficacy of PI for detecting haemodynamic stress responses to insertion of i-gel, laryngeal mask ...
Hosam M Atef, Salah Abd Fattah, Mohammed Emad Abd Gaffer, Ahamed Abd Al Rahman   +3 more
doaj   +1 more source

A study to evaluate the change in perfusion index as an indicator of successful ultrasound-guided supraclavicular block

Indian Journal of Anaesthesia, 2021
Background and Aims: Perfusion index (PI) is a new simple, objective and non-invasive method for evaluation of the success of central neuraxial and peripheral nerve blocks.
Jatin Lal, Mamta Bhardwaj, Aanchal Malik, Teena Bansal   +3 more
doaj   +1 more source

Measurement of myocardial perfusion index.

, 2016
(A) Segment from representative mid-ventricular slice during first-pass perfusion imaging during peak dose dobutamine stress. Red region of interest defines the middle of the left ventricle (LV) for measuring the slope of blood, and the green circle ...
Craig A. Hamilton (844918), Sandra Soots (844920), Michael E. Hall (844915), Haroon Chughtai (844916), Jennifer H. Jordan (844919), W. Gregory Hundley (332555), Timothy M. Morgan (844917), Tina E. Brinkley (337907), R. Brandon Stacey (380950)   +8 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy. [PDF]

, 2016
The exclusion of collateral ventilation (CV) and other factors affect the clinical success of endoscopic lung volume reduction (ELVR). However, despite its benefits, the outcome of ELVR remains difficult to predict.
Schürmann, Dirk, Herzog, Dominik, Pöllinger, Alexander, Doellinger, Felix, Theilig, Dorothea, Poellinger, Alexander, Thomsen, Christian, Suttorp, Norbert, Schreiter, Nils, Schreiter, Vera, Temmesfeld-Wollbrueck, Bettina, Hubner, Ralf-Harto, Hippenstiel, Stefan, Schuermann, Dirk   +13 more
core   +2 more sources