Results 51 to 60 of about 4,249,101 (249)

Laser speckle contrast imaging to monitor microcirculation: An effective method to predict outcome in patients with sepsis and septic shock

Frontiers in Bioengineering and Biotechnology, 2023
Background: This study examines the microcirculation of patients with sepsis and septic shock using Laser Speckle Contrast Imaging (LSCI) technology, to enhance monitoring and predict outcomes of sepsis and septic shock.Methods: From 01 July 2021, to 31 ...
Zhengshang Ruan, Ran Li, Wenwen Dong, Zhilei Cui, Hui Yang, Rongrong Ren   +5 more
doaj   +1 more source

Peripheral Perfusion Index as a Marker of Sepsis in Preterm Neonates

Journal of Tropical Pediatrics, 2021
Abstract Background: Neonatal sepsis is a major contributor to neonatal mortality in India. Blood culture, the gold standard for the diagnosis of sepsis takes 48-72 hours while the serological markers have suboptimal diagnostic test characteristics.
Jasmine Singh, Suksham Jain, Deepak Chawla, Shivani Randev, Supreet Khurana   +4 more
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Perfusion index as a predictor of successful PNS-guided supraclavicular block: A prospective study [PDF]

Journal of Preventive and Complementary Medicine
Background: The perfusion index (PI) is a simple, non-invasive measure obtained via pulse oximetry that reflects peripheral blood flow changes. Alterations in PI can signify shifts in perfusion dynamics during a brachial plexus block.
Monika Gandhi, Khushboo Ranpise, Aseem Sharma, Manish Banjare   +3 more
doaj   +1 more source

Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. [PDF]

PLoS ONE, 2014
PurposeChildhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways.
Bo-Qia Xie, Wei Wang, Wen-Qian Zhang, Xin-Hua Guo, Min-Fu Yang, Li Wang, Zuo-Xiang He, Yue-Qin Tian   +7 more
doaj   +1 more source

A study to evaluate the change in perfusion index as an indicator of successful ultrasound-guided supraclavicular block

Indian Journal of Anaesthesia, 2021
Background and Aims: Perfusion index (PI) is a new simple, objective and non-invasive method for evaluation of the success of central neuraxial and peripheral nerve blocks.
Jatin Lal, Mamta Bhardwaj, Aanchal Malik, Teena Bansal   +3 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Clinical and CMR characteristics in NICM patients with vs. without impaired myocardial perfusion reserve index.

, 2022
Clinical and CMR characteristics in NICM patients with vs. without impaired myocardial perfusion reserve index.
Jeremy A. Slivnick (14142030), Vien T. Truong (4675486), Karolina M. Zareba (14142033), Wojciech Mazur (4675495), Philip Binkley (8055227), Alexis Barnes (14142039), Ellen Liu (14142036)   +6 more
core   +1 more source

Optimizing the timing of painless gastroscope insertion: integrating advanced monitoring tools to enhance safety and efficacy: a narrative review

Frontiers in Medicine
Painless gastroscopy demonstrates significant improvement in patient comfort and examination compliance, which might indicate that the procedure has become commonly used in clinical practice. However, the critical step of accurately determining insertion
Chunyan Li, Hongmei Zhou, Shuai Kang, Yipan Wu, Li Hu, Yun Xiong   +5 more
doaj   +1 more source