Results 31 to 40 of about 1,931 (131)

Advances in Erectile Dysfunction Management: What Does Work

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent and multifactorial disorder that substantially affects quality of life. Pathophysiology includes vascular, neurogenic, drug‐induced, and psychogenic causes, and frequently coexists with cardiometabolic disease.
Jolie Shen, Daye Park, Jasper Bash, Juan Andino   +3 more
wiley   +1 more source

Lipid pathway deregulation in advanced prostate cancer [PDF]

, 2018
The link between prostate cancer (PC) development and lipid metabolism is well established, with AR intimately involved in a number of lipogenic processes involving SREBP1, PPARG, FASN, ACC, ACLY and SCD1.
Ahmad, Imran, Galbraith, Laura, Leung, Hing Y.   +2 more
core   +1 more source

Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF-1 upregulation of TUBB2B beta-tubulin isoform [PDF]

, 2021
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect response to Docetaxel (DCTX) and the mechanisms associated. Conditioned medium was
Beguinot F., Cennamo M., Crocetto F., Ferro M., Formisano P., Guadagno E., Imbimbo C., Insabato L., La Civita E., Liguoro P., Liotti A., Mirone V., Palmieri A., Terracciano D.   +13 more
core   +1 more source

Clinical Applications of Electrical Conductivity Imaging Using MRI

Journal of Magnetic Resonance Imaging, Volume 63, Issue 5, Page 1224-1245, May 2026.
ABSTRACT Magnetic resonance imaging (MRI) has emerged as a noninvasive technique for probing the electrical properties of biological tissues: electrical conductivity and relative permittivity. This review focuses on the electrical conductivity and provides a comprehensive overview of applications across both low‐ and high‐frequency regimes.
Stefano Mandija, Khin Khin Tha, Nitish Katoch, Cihan Göksu, Ulrich Katscher, Rosalind Sadleir, Kyu‐Jin Jung, Jierong Luo, Ilias I. Giannakopoulos, Dong‐Hyun Kim, Karin Shmueli, Riccardo Lattanzi, Yusuf Ziya Ider, Axel Thielscher, Cornelis van den Berg   +14 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro [PDF]

, 2012
Background - Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown.
Cunha, Virgínia, Fraga, Avelino, Freitas, Mariana, Lobato, Carlos, Lobo, Francisco, Lopes, Carlos, Medeiros, Rui, Monteiro, Cátia, Morais, António, Mota-Pinto, Anabela, Oliveira, Jorge, Oliveira, Maria José, Pina, Francisco, Príncipe, Paulo, Ribeiro, Ricardo, Sanches-Magalhães, José, Silva, Vítor   +16 more
core   +4 more sources

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Pelvic Exenteration: Oncological and Surgical Outcomes From a Single Tertiary Statewide Service

ANZ Journal of Surgery, Volume 96, Issue 4, Page 964-971, April 2026.
ABSTRACT Background Advancements in the multidisciplinary management of locally advanced and recurrent rectal cancer, as well as advanced pelvic malignancies, have significantly improved oncological outcomes. Pelvic exenteration is a complex procedure involving en bloc resection of the involved organs with the aim of achieving a microscopic negative ...
Elena T. Blyth, Michael R. Lonne, Kandice B. Keogh, Jane E. Theodore, Craig A. Harris   +4 more
wiley   +1 more source

Additional file 1: Figure S1. of Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue

, 2017
Representative histology of a 103-week-old mouse (#1825) that developed poorly differentiated tumor in the prostate. CD45 stains for all leukocyte antigens in the infiltrates. Supplement Figure 2. Exogenous human IL-6 induces paracrine mouse IL-6 expression in two mouse prostate tumor cell lines, the TRAMP-C2 and MyC-Cap.
Liu, Gang, Zhang, Jinyu, Frey, Lewis, Gang, Xiao, Kongming Wu, Liu, Qian, Lilly, Michael, Wu, Jennifer   +7 more
openaire   +1 more source

From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management

JCC Plus, Volume 1, Issue 2, March 2026.
Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi, Alejandra A. Carriles, Samuel Elias Pineda Chavez, Stefanos Bonovas, Arianna Dal Buono, Cristina Bezzio, Alessandro Armuzzi, Stefania Vetrano   +7 more
wiley   +1 more source