Results 51 to 60 of about 478,697 (222)

Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization

eLife, 2022
During threat exposure, survival depends on defensive reactions. Prior works linked large glutamatergic populations in the midbrain periaqueductal gray (PAG) to defensive freezing and flight, and established that the overarching functional organization ...
Mimi Q La-Vu, Ekayana Sethi, Sandra Maesta-Pereira, Peter J Schuette, Brooke C Tobias, Fernando MCV Reis, Weisheng Wang, Anita Torossian, Amy Bishop, Saskia J Leonard, Lilly Lin, Catherine M Cahill, Avishek Adhikari   +12 more
doaj   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Modulação das funções do sistema glutamatérgico pelo receptor serotoninérgico 5-HT1A da substância cinzenta periaquedutal dorsal no comportamento defensivo de ratos [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Vários estudos têm caracterizado o envolvimento da substância cinzenta periaquedutal dorsal (SCPd) nas respostas ...
Moraes, Cladis Loren Kiefer
core  

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Connectivity of the human periventricular—periaqueductal gray region

Journal of Neurosurgery, 2005
Object. The periventricular gray (PVG) zone and its continuation, the periaqueductal gray (PAG) substance, have been targets for deep brain stimulation (DBS) in the alleviation of intractable pain for longer than two decades. Nevertheless, the anatomical connectivity of this region has been fairly poorly defined.
Sillery, E, Bittar, R, Robson, M, Behrens, T, Stein, J, Aziz, T, Johansen-Berg, H   +6 more
openaire   +2 more sources

Dupla dissociação da função dos receptores NMDA da substância cinzenta periaquedutal dorsolateral rostral e caudal no medo inato e condicionado ao ador de gato [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O odor de predador tem sido utilizado como estímulo aversivo em animais de laboratório na tentativa de compreender ...
Souza, Rimenez Rodrigues de
core  

Global DNA Methylation in the Limbic System of Cattle

Epigenomes, 2019
To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers.
Bonnie Cantrell, Hannah Lachance, Brenda Murdoch, Julia Sjoquist, Richard Funston, Robert Weaber, Stephanie McKay   +6 more
doaj   +1 more source

Overexpression of BDNF in the ventrolateral periaqueductal gray regulates the behavior of epilepsy–migraine comorbid rats

Brain and Behavior, 2022
Objective To investigate the effects of brain‐derived neurotrophic factor (BDNF) overexpression in the ventrolateral periaqueductal gray (vlPAG) on behavioral changes in epilepsy–migraine comorbid rats.
Long Wang, Lu‐Lan Fu, Zi‐Ru Deng, Juan Zhang, Mei‐Dan Zu, Jun‐Cang Wu, Yu Wang   +6 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source