Results 331 to 340 of about 106,411 (380)

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer's disease. [PDF]

Brain
Hamid M, Saha Detroja T, Tripathy SJ, Menon V, Xu J, Yu L, Wang Y, Buchman AS, Bennett DA, De Jager PL, Lim ASP.   +10 more
europepmc   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Integrin α8-Mediated Pericyte Morphogenesis Controls Blood-Brain Barrier Integrity. [PDF]

Adv Sci (Weinh)
Gong CX, Hu LL, Jiang L, Shi PX, Zhang S, Zhao Y, Wang BQ, Cheng XF, He CK, Lin S, Dai Y, Meng ZY, Zhao CH, Sun BL, Xie Q, Li FF, Yang QW.   +16 more
europepmc   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Pericytes repair engineered defects in the basement membrane to restore barrier integrity in an <i>in vitro</i> model of the blood-brain barrier. [PDF]

Mater Today Bio
Trempel MA, Du Y, Widom LP, Reitz EE, Feidler AM, Kasap P, Engelhardt B, Gaborski TR, Gelbard HA, Terrando N, McGrath JL.   +10 more
europepmc   +1 more source

Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study

The Journal of Physiology, EarlyView.
Abstract figure legend Longitudinal assessment of sex differences in cerebrovascular ageing over a ∼6 year period: the Brain in Motion study. Cerebrovascular function was assessed at baseline (T1) and at a follow‐up (T2) ∼6 years later, at rest, during euoxic hypercapnia and while engaging in submaximal exercise. Over the follow‐up period females had a
Connor Snow, Alison M. H. Donald, Kian M. Pelechaty, Jordan Gibson, Michael D. Hill, Jean M. Rawling, Jayna Holroyd‐Leduc, Kara Nerenberg, Jessalyn K. Holodinsky, R. Stewart Longman, Marc J. Poulin   +10 more
wiley   +1 more source

When Mitochondria Falter, the Barrier Fails: Mechanisms of Inner Blood-Retinal Barrier (iBRB) Injury and Opportunities for Mitochondria-Targeted Repair. [PDF]

Int J Mol Sci
Chen Z, Jin Q, Li J, Li K.
europepmc   +1 more source

Expression of Nrf2 and HO-1 proteins in the vascular endothelial cell and pericyte groups after exposure to iAs or Mn alone and coexposure to iAs and Mn.

Toshiaki Hitomi (213290), Hiroko Okuda (843248), Ayako Takata (7526720), Hiroshi Yamauchi (71653)   +3 more
openalex   +1 more source

Single-Cell RNA Sequencing Reveals Pericytes Acquire a Fibrotic Phenotype and Promote Mesenteric Adipose Tissue Fibrosis in Crohn's Disease. [PDF]

J Inflamm Res
Zhang D, Yu A, He M, Zhou Q, Sun S, Bai L, Xie F.   +6 more
europepmc   +1 more source