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Pericytes in Metastasis

2019
Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of ...
Pieterse, Z., Sinha, D., Kaur, Pritinder
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Pericyte morphology and function.

Histology and histopathology, 2021
The proper delivery of blood is essential for healthy neuronal function. The anatomical substrate for this precise mechanism is the neurovascular unit, which is formed by neurons, glial cells, endothelia, smooth muscle cells, and pericytes. Based on their particular location on the vessel wall, morphology, and protein expression, pericytes have been ...
Luis, Alarcon-Martinez   +2 more
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Pericyte differentiation.

Clinical orthopaedics and related research, 1995
Pericytes are defined in vivo by their location: They are embedded within the basement membrane of microvessels. They form an integral part of the microvascular wall and are believed to participate in angiogenesis, although their precise role is not clear. Pericytes derived from the retinal microvasculature have been cultured and identified by a series
Schor, A M   +4 more
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Diversity Within Pericytes

Clinical and Experimental Pharmacology and Physiology, 2000
SUMMARY1. Pericytes are cells of microvessels (arterioles, capillaries and venules) that wrap around endothelial cells. They are most abundant on venules and are common on capillaries.2. The pericyte population is highly variable between different tissues and organs, probably in a manner reflecting postarteriolar hydrostatic pressures.
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Pericytes and vascular stability

Experimental Cell Research, 2006
Newly formed endothelial tubes are initially unstable and subsequently become stabilized through the formation of a perivascular matrix and the association with pericytes. The presence of pericyte per se is not sufficient for vascular stability. Instead, specific qualities of the cells are required that seem to correlate with marker expression and the ...
Desiree, von Tell   +2 more
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Focus on cardiac pericytes

Pflügers Archiv - European Journal of Physiology, 2013
The wall of myocardial terminal vessels, consisting of a continuous endothelial tube with an adventitial coat of pericytes in their extracellular matrix, constitutes a remarkably tight barrier to solute transport between the blood and the parenchyma. This constructional principle of precapillary arterioles, capillaries and postcapillary venules extends
Stephan, Nees   +2 more
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Challenges in Pericyte Research: Pericyte-Specific and Subtype-Specific Markers

Translational Stroke Research, 2022
Pericytes are a heterogenous population that plays multiple important roles in both physiological and pathological conditions. Although many markers and transgenic mouse lines have been used to identify pericytes, these tools all have limitations. For example, many of them are not pericyte-specific and none of them are able to distinguish different ...
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Pericytes in the eye

Pflügers Archiv - European Journal of Physiology, 2013
Pericytes in the retina differ from pericytes in many other organs by their high density and their cooperative role in the neurovascular unit. Their diverse ontogeny and the fact that not one pericyte marker identifies the entire population suggest also functional plurality in the retina, including invading cells of mesenchymal origin.
Frederick, Pfister   +3 more
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Pericytes in the Heart

2019
Mural cells known as pericytes envelop the endothelial layer of microvessels throughout the body and have been described to have tissue-specific functions. Cardiac pericytes are abundantly found in the heart, but they are relatively understudied.
Linda L, Lee, Vishnu, Chintalgattu
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Pericytes and ocular diseases

Experimental Eye Research, 2008
Pericytes are vascular mural cells which play multiple roles in angiogenesis and maintenance of blood vessel morphology and stability. In this review, we analyze recent data on the participation of pericytes in the pathogenesis of proliferative and non-proliferative diabetic retinopathy, as well as an emerging role in other angiogenic ocular diseases ...
Rūta, Motiejūnaite   +1 more
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