Results 111 to 120 of about 17,637,970 (344)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Short period and long period in macroeconomics: an awkward distinction [PDF]
: The aim of this paper is to show that the use and meaning of the well-known concepts of short period and long period is often unclear and may be seriously misleading when applied to macroeconomic analysis.
Eleonora Sanfilippo
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Biological Survey on cuttlefishes of Systan-o-Baluchistan waters (Southeastern Iran) Page 56-69
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1993 Species of cephalopoda and biological characteristics of Sepia pharaonis, were investigated in tho fishing grounds of Goitre" to "Gallak" corresponding to 61,31 - 59,30 eastern longitude and 25,10 - 25,23 northern latitude respectively.
T. Valinasab
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Definition of basic and supporting parts of Alfa foils, a.s. planning system [PDF]
Acta Montanistica Slovaca, 2008 Aggregate planning cummulates into one target capacity, materials, economy and technology rules with aim to minimizesubjective approaches at the production plan designing and utilization of automatic (pseudoexpert) system for making productionplanning ...
Zuzana Marková +2 more
doaj
Period polynomials and Ihara brackets
, 2006 Schneps [J. Lie Theory 16 (2006), 19--37] has found surprising links between Ihara brackets and even period polynomials. These results can be recovered and generalized by considering some identities relating Ihara brackets and classical Lie brackets. The
Luque, Jean-Gabriel +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source