Results 91 to 100 of about 17,637,970 (344)

Chronotype and Social Jetlag: A (Self-) Critical Review

open access: yesBiology, 2019
The Munich ChronoType Questionnaire (MCTQ) has now been available for more than 15 years and its original publication has been cited 1240 times (Google Scholar, May 2019).
Till Roenneberg   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

The period functions' higher order derivatives [PDF]

open access: yes, 2012
We prove a formula for the $n$-th derivative of the period function $T$ in a period annulus of a planar differential system. For $n = 1$, we obtain Freire, Gasull and Guillamon formula for the period's first derivative \cite{FGG}.
Sabatini, Marco
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Educational differences in period fertility: The case of South Korea, 1996-2010

open access: yesDemographic Research, 2018
Background: Previous studies on education-specific fertility in South Korea suggest that fertility differentials across educational groups have been diminishing in recent years. Objective: This study aims to verify whether education-specific fertility
Eunkoo Lee
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Corpus-driven Bantu Lexicography Part 1: Organic Corpus Building for Lusoga

open access: yesLexikos, 2018
This article is the first in a trilogy that deals with corpus-driven Bantu lexicography, which is illustrated for Lusoga. The focus here is on the building of a so-called 'organic corpus' from scratch, while the next two instalments will deal with the ...
Gilles-Maurice de Schryver
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

The dependency between annual air temperature and solar activity. A case study of Warsaw in 1951–2010.

open access: yesMiscellanea Geographica: Regional Studies on Development, 2017
The paper demonstrates a dependency between the annual average daily air temperature course (cycle) in Warsaw and the profile of annual solar activity linked to rotation (with a period of 25–31 days). Waves of cold (ΔT
Boryczka Jerzy   +3 more
doaj   +1 more source

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