Results 91 to 100 of about 5,403,115 (267)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Determining the Impact of Menstrual Cycle on Collegiate Athletes: Self-reported Health Issues, Sports Performance, and Willingness to Discuss Regarding Menstruation

Physical Education Theory and Methodology
Background. Gaining a comprehensive understanding of the menstrual cycle, its associated health concerns, and the subsequent effects on athlete performance could facilitate the formulation of educated and tailored strategies for training and ...
Yetty Septiani Mustar, Bayu Agung Pramono, Febby Alfu Khoirun Nissa, Indra Himawan Susanto, Anna Noordia, Dita Yuliastrid   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Comparison of growth, morphometric and meristic parameters of hybrids produced by crossing between Beluga (Huso huso) and Persian Sturgeon (Acipenser persicus)

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2006
Reciprocal crosses between Beluga and Persian Sturgeon in four treatments and three replications were conducted and reproduction metrics including number of eggs per gram, percentage of fertilization, and survival rate were assessed. Also, we measured 32
M. Porkazemi1; M. Mohseni1; M. Noroz fashkhami2; A. Taheri3; F. Chakmedoz1; Sh. Baradaran noveiri2; M. Yarmohmmadi2; M. Hassanzadeh2; A. Halajian2; R. Kazemi2; M. Bahmani2
doaj  

Measures to Improve the Legal Principles of the Extinctive Prescription for the Right of Remuneration for Employee Inventions

Journal of Intellectual Property
According to the Supreme Court’s legal principles on the extinctive prescription for right of remuneration for employee invention, if there are no in-house employee invention regulations, or even if they exist, the time and procedure for payment of ...
Joohwan Lee
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Regulation of long-term memory by a few clock neurons in Drosophila

Biophysics and Physicobiology
Identification of the neural circuits in the brain regulating animal behavior and physiology is critical for understanding brain functions and is one of the most challenging goals in neuroscience research.
Rei Shirakawa, Yuto Kurata, Takaomi Sakai   +2 more
doaj   +1 more source

Recurrence of hot days in the Stavropol krai under current climate conditions

Наука. Инновации. Технологии
Heat is an unfavorable weather phenomenon, as it poses a serious threat to many sectors of the national economy: agriculture, energy, construction, etc.
Yu. L. Smerek, G. Kh. Badakhova, V. I. Volkova, M. V. Barekova   +3 more
doaj   +1 more source