Results 81 to 90 of about 17,637,970 (344)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Дороги і мостиntroduction. In order to improve the design methodology, particularly in the calculation of transport construction objects made of metal corrugated structures (MCS) with increased hole size (small bridges and arch-shaped overpasses, drainage pipes under ...
Volodymyr Abramov
doaj +1 more source
The Short Rotation Period of Nereid
, 2003 We determine the period, p = 11.52 \pm 0.14 h, and a light curve peak-to-peak amplitude, a = 0.029 \pm 0.003 magnitudes, of the Neptunian irregular satellite Nereid. If the light curve variation is due to albedo variations across the surface, rather than
Brown M. J. I. +8 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Annales Universitatis Paedagogicae Cracoviensis. Studia Poetica, 2018 The World of Girls Seen Trough the Women Eyes on the Two Examples:Królestwo dziewczynki Iwony Chmielewskiej and Pierwsze koty robaczywkiKariny Bonowicz Thie article presents two works writen for young people, that is drawing out the subject of girls ...
Elżbieta Kruszyńska
doaj +1 more source
Connecting period-doubling cascades to chaos [PDF]
, 2010 The appearance of infinitely-many period-doubling cascades is one of the most prominent features observed in the study of maps depending on a parameter. They are associated with chaotic behavior, since bifurcation diagrams of a map with a parameter often
Sander, Evelyn, Yorke, James A.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source