Results 61 to 70 of about 5,403,115 (267)

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

eLife, 2014
The mammalian circadian clock is driven by a transcriptional–translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of the clock depends on the complex formation and periodic turnover of the Period and Cryptochrome proteins,
Shannon N Nangle, Clark Rosensweig, Nobuya Koike, Hajime Tei, Joseph S Takahashi, Carla B Green, Ning Zheng   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Methodology for practical calculation of arched road structures made of corrugated metal

Дороги і мости
Introduction. To spread the practice of transport construction of road structures made of corrugated metal under the embankment, which have long been and successfully used in different countries of the world instead of small and medium-sized bridges ...
Volodymyr Abramov
doaj   +1 more source

Consistency Analysis of Precipitation Characteristics of Mu Us Sandy Land Based on Daily Precipitation Data

Renmin Zhujiang, 2021
Mu Us Sandy Land is located in Yulin city of Shaanxi province and Ordos city of Inner Mongolia Autonomous Region,where the ecological and hydrological system is relatively fragile.However,precipitation is an important controlling factor to the evolution ...
MA Lan, LIU Dengfeng, BAI Bing, REN Mengzhi, HUANG Qiang, LIN Mu   +5 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Supplement to the methodology for calculating dridge structures made of corrugated metal taking into account the condituons of fixing the structures to the foundation

Дороги і мости
Introduction. The results of research and developments on supplementing the methodology for calculating corrugated metal bridge structures on highways, taking into account the actual conditions of fastening structures to the foundation, are presented ...
Volodymyr Abramov
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Analysis of different approaches to the calculation and design of road structures from corrugated metal

Дороги і мости
ntroduction. In order to improve the design methodology, particularly in the calculation of transport construction objects made of metal corrugated structures (MCS) with increased hole size (small bridges and arch-shaped overpasses, drainage pipes under ...
Volodymyr Abramov
doaj   +1 more source