Results 151 to 160 of about 356,744 (339)

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method [PDF]

arXiv
Numerous biological processes accelerate as temperatures increase, but the period of circadian rhythms remains constant, known as temperature compensation, while synchronizing with the 24h light-dark cycle. We theoretically explores the possible relevance of waveform distortions in circadian gene-protein dynamics to the temperature compensation and ...
arxiv  

Structure-function analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation [PDF]

, 2022
Bin Wang, Elizabeth‐Lauren Stevenson, Jay Dunlap   +2 more
openalex   +1 more source

Period protein from the giant silkmoth antheraea pernyi functions as a circadian clock element in drosophila melanogaster

Neuron, 1995
Homologs of the Drosophila clock gene per have recently been cloned in Lepidopteran and Blattarian insect species. To assess the extent to which clock mechanisms are conserved among phylogenetically distant species, we determined whether PER protein from the silkmoth Antheraea pernyi can function in the Drosophila circadian timing system.
M Imbalzano, J D Levine, Ivo Sauman, Steven M. Reppert, F R Jackson   +4 more
openaire   +3 more sources

Beyond adult models: Tribolium castaneum larval timekeeping reveals unexpected robustness and insights into circadian clock

Insect Science, EarlyView.
Abstract Circadian rhythms are self‐sustained endogenous oscillations that are found in all living organisms. In insects, circadian rhythms control a wide variety of behavioral and physiological processes, including feeding, locomotion, mating, and metabolism.
Miriam Benita, Ariel Menahem, Animesha Rath, Inon Scharf, Daphna Gottlieb   +4 more
wiley   +1 more source

"Time sweet time": circadian characterization of galectin-1 null mice

Journal of Circadian Rhythms, 2010
Background Recent evidence suggests a two-way interaction between the immune and circadian systems. Circadian control of immune factors, as well as the effect of immunological variables on circadian rhythms, might be key elements in both physiological ...
Rabinovich Gabriel A, Poirier Francoise, Croci Diego O, Casiraghi Leandro P, Golombek Diego A   +4 more
doaj   +1 more source

Drosophila doubletime Mutations Which either Shorten or Lengthen the Period of Circadian Rhythms Decrease the Protein Kinase Activity of Casein Kinase I [PDF]

, 2003
Fabian Preuss, Jin-Yuan Fan, Madhavi Kalive, Shu Bao, Eric Schuenemann, Edward S. Bjes, Jeffrey L. Price   +6 more
openalex   +1 more source

Navigating challenges and adherence in time‐restricted eating: A qualitative study

Nutrition &Dietetics, EarlyView.
Abstract Aims Adherence to any dietary approach is crucial for achieving long‐term benefits. This qualitative study aims to explore the facilitators and barriers to adherence, and how individuals in community settings navigate time‐restricted eating in their daily lives.
Hilmi S. Rathomi, Nahal Mavaddat, Judith M. Katzenellenbogen, Sandra C. Thompson   +3 more
wiley   +1 more source

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Nature Communications, 2018
The molecular mechanisms that define the periodicity or rate of the circadian clock are not well understood. Here the authors use a multidisciplinary approach and identify a mechanism for period regulation that depends on the affinity of the core clock ...
Clark Rosensweig, Kimberly A. Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S. Takahashi, Carla B. Green   +7 more
doaj   +1 more source